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Cat. No.: HY-P86740A

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PTEN Antibody (YA6432)(PBS only)

Name: PTEN Antibody (YA6432)(PBS only)
Brand: MedChemExpress
SKU: HY-P86740A
Availability: PreOrder

(Synonyms: ITGA 2; MGC11227; MHAM; MMAC 1; MMAC1; Bannayan Zonana; BZS a; Multiple hamartoma(Cowden syndrome); Mutated in Mutiple Advanced Cancers 1; Phosphatase and Tensin Homolog; Phosphatidylinositol 345 trisphosphate 3 phosphatase and dual specificity protein phosphatase PTEN; Phosphatidylinositol 345 trisphosphate 3 phosphatase; Platelet antigen BR; PTEN 1; PTEN1; Tensin homolog; TEP 1; TEP1; VLA 2 Receptor alpha Subunit.)

PTEN Antibody (YA6432) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to PTEN.

For research use only. We do not sell to patients.

Host:
Mouse
Isotype:
IgG
Application:
IHC-P, IHC-F, ICC/IF, IF-Tissue
Reactivity :
Human, Mouse, Rat

Formulation:
Supplied in PBS.

Conjugation:
Non-conjugated

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications
Product Details
Product Properties
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- Storage & Stability
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Background
Documentation
Help & FAQs
Classifications
Bioz

Applications

Application	IHC-P IHC-P: Immunohistochemistry-Paraffin	IHC-F IHC-F: Immunohistochemistry-Frozen	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence
Dilution Ratio	1:100-500	1:100-500	1:100-200	1:100-500

Product Details

Description

PTEN Antibody (YA6432) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to PTEN.

Host Mouse
Clonality Monoclonal
Species Reactivity
Human, Mouse, Rat
Calculated Molecular Weight Predicted band size: 44 kDa

Immunogen

KLH conjugated synthetic peptide derived from human PTEN

Purification

affinity purified.

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

Appearance

Solution
Formulation

Supplied in PBS.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Background

Function

PTEN (Phosphatase and tensin homologue deleted on chromosome 10), a phosphoinositide 3-phosphatase, is an important regulator of insulin-dependent signaling. The loss or impairment of PTEN results in an antidiabetic impact, which led to the suggestion that PTEN could be an important target for drugs against type II diabetes. PTEN has a much wider active site cleft enabling it to bind the PtdIns (3, 4, 5) P3 substrate. a highly potent and specific inhibitor of PTEN that increases cellular PtdIns (3, 4, 5) P3 levels, phosphorylation of Akt, and glucose uptake in adipocytes at nanomolar concentrations.
Subcellular Localization

Cytoplasm; Nucleus; Nucleus, PML body; Cell projection, dendritic spine; Postsynaptic density; Secreted
Expression

Tissue_specificity:It is expressed at high levels in all adult tissues, including the heart, brain, placenta, lungs, liver, muscles, kidneys, and pancreas.

Induction:Down-regulated by TGFB1
Subunit

Monomer. The unphosphorylated form interacts with the second PDZ domain of MAGI2 and with DLG1 and MAST2 in vitro (PubMed:10646847, PubMed:10760291, PubMed:11707428). Interacts with MAGI2, MAGI3, MAST1 and MAST3, but neither with MAST4 nor with DLG5; interaction with MAGI2 increases protein stability (PubMed:10748157, PubMed:15951562). Interacts with NEDD4 (PubMed:17218260). Interacts with NDFIP1 and NDFIP2; in the presence of NEDD4 or ITCH, this interaction promotes PTEN ubiquitination (PubMed:20534535, PubMed:25801959). Interacts (via C2 domain) with FRK (PubMed:19345329). Interacts with USP7; the interaction is direct (PubMed:18716620). Interacts with ROCK1 (By similarity). Interacts with XIAP/BIRC4 (PubMed:19473982). Interacts with STK11; the interaction phosphorylates PTEN (PubMed:15987703). Interacts with PPP1R16B (PubMed:25007873). Interacts with NOP53; regulates PTEN phosphorylation and increases its stability (PubMed:15355975). Interacts (via PDZ domain-binding motif) with DLG4; the interaction is induced by NMDA and is required for PTEN location at postsynaptic density (By similarity). Interacts with the regulatory p85 subunit of the PI3K kinase complex and with Rho GTPase-activating protein DLC1; in resting cells, interacts (via C2 tensin-type domain) with p85 but, following growth factor stimulation, PTEN is phosphorylated which leads to weakened interaction with p85 and enhanced interaction (via C2 tensin-type domain) with DLC1 while p85 interaction with TNS3 increases (PubMed:26166433)
SwissProt ID

P60484
Gene ID

5728 [NCBI]
Synonyms

ITGA 2; MGC11227; MHAM; MMAC 1; MMAC1; Bannayan Zonana; BZS a; Multiple hamartoma(Cowden syndrome); Mutated in Mutiple Advanced Cancers 1; Phosphatase and Tensin Homolog; Phosphatidylinositol 345 trisphosphate 3 phosphatase and dual specificity protein phosphatase PTEN; Phosphatidylinositol 345 trisphosphate 3 phosphatase; Platelet antigen BR; PTEN 1; PTEN1; Tensin homolog; TEP 1; TEP1; VLA 2 Receptor alpha Subunit.