PVRL1 Antibody (YA8081)(PBS only)
(Synonyms: CD111; CLPED1; ED4; HIgR; HV1S; HVEC; nectin-1; OFC7; PRR; PRR1; PVRL1; PVRR; PVRR1; SK-12)PVRL1 Antibody (YA8081) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PVRL1.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, ICC/IF
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:150-200 | 1:100-200 |
Product Details
PVRL1 Antibody (YA8081) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PVRL1.
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Host Mouse
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 54 kDa
Full length human recombinant protein of human PVRL1 produced in HEK293T cell.
Affinity purified
Non-conjugated
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
PVRL1 cell adhesion molecule that promotes cell-cell contacts and plays important roles in the development of the nervous system. Acts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4. Involved in axon guidance by promoting contacts between the commissural axons and the floor plate cells. Involved in synaptogegesis. Has some neurite outgrowth-promoting activity. Promotes formation of checkerboard-like cellular pattern of hair cells and supporting cells in the auditory epithelium via heterophilic interaction with NECTIN3: NECTIN1 is present in the membrane of hair cells and associates with NECTIN3 on supporting cells, thereby mediating heterotypic adhesion between these two cell types. Required for enamel mineralization|(Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1, herpes simplex virus 2/HHV-2, and pseudorabies virus/PRV. Constitutes the major receptor for herpes simplex virus 1/HHV-1 entry into host cells[1][2][3][4][5][6][7][8][9][10][11][12].
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Subcellular Localization
Cell membrane,Cell junction, adherens junction,Presynaptic cell membrane,Cell membrane,Cell membrane,Secreted
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Isoforms & Post-Translational Modification
Q15223 has three isomers: Q15223-1: 57158 Da (predicted); Q15223-2: 50721 Da (predicted); Q15223-3: 39150 Da (predicted).
(Microbial infection) Ubiquitinated by CBL following infection by herpes simplex virus 1/HHV-1 and association with HHV-1 envelope glycoprotein D, leading to its removal from cell surface -
Subunit
Cis- and trans-homodimer (PubMed:22902367)
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SwissProt ID
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Synonyms
CD111; CLPED1; ED4; HIgR; HV1S; HVEC; nectin-1; OFC7; PRR; PRR1; PVRL1; PVRR; PVRR1; SK-12
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