RAB6A Antibody
(Synonyms: RAB6, RAB6A, Ras-related protein Rab-6A, Rab-6)RAB6A Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to RAB6A.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB, IHC-P, ICC/IF
-
Reactivity :
Human, Mouse, Rat
-
Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 | 1:50-200 |
Product Details
RAB6A Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to RAB6A.
-
Host Rabbit
-
Clonality Polyclonal
-
Species ReactivityHuman, Mouse, Rat
-
Observed Molecular WeightObserved band size: 24 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 23 kDa
Synthetic peptide corresponding to the center region of human RAB6A.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Solution
-
Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
RAB6A is a The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB6A acts as a regulator of COPI-independent retrograde transport from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Recruits VPS13B to the Golgi membrane. Plays a role in neuron projection development (Probable)[1][2].
-
Subcellular Localization
Golgi apparatus membrane; Cytoplasmic vesicle, secretory vesicle, acrosome membrane
-
Expression
Tissue_Specificity: Ubiquitous. -
Isoforms & Post-Translational Modification
RAB6A has 4 isoforms, P20340-1: amino acid length is 208, molecular weight is 23593 Da (predicted); P20340-2: amino acid length is 208, molecular weight is 23549 Da (predicted); P20340-3: amino acid length is 104, molecular weight is 11715 Da (predicted); P20340-4: amino acid length is 175, molecular weight is 19935 Da (predicted).发生异戊二烯化修饰RAB6A 存在 4 个异构体，P20340-1：氨基酸个数为 208 个，分子量为 23593 Da (预测)；P20340-2：氨基酸个数为 208 个，分子量为 23549 Da (预测)；P20340-3：氨基酸个数为 104 个，分子量为 11715 Da (预测)；P20340-4：氨基酸个数为 175 个，分子量为 19935 Da (预测)。Prenylated
-
Subunit
Interacts (GTP-bound) with DYNLRB1; the interaction is direct.
-
SwissProt ID
-
Synonyms
RAB6, RAB6A, Ras-related protein Rab-6A, Rab-6
Documentation
[1]. Matsuto M, et al. Reconstitution of the targeting of Rab6A to the Golgi apparatus in semi-intact HeLa cells: A role of BICD2 in stabilizing Rab6A on Golgi membranes and a concerted role of Rab6A/BICD2 interactions in Golgi-to-ER retrograde transport. Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2592-609. [Content Brief]
[2]. Seifert W, et al. Cohen syndrome-associated protein COH1 physically and functionally interacts with the small GTPase RAB6 at the Golgi complex and directs neurite outgrowth. J Biol Chem. 2015 Feb 6;290(6):3349-58. [Content Brief]
Powered by Bioz
