REG3G Antibody (YA7138)
(Synonyms: PAP1B, UNQ429/PRO162, REG3G, Regenerating islet-derived protein 3-gamma, REG-3-gamma, Pancreatitis-associated protein 1B, Pancreatitis-associated protein IB, Regenerating islet-derived protein III-gamma, PAP-1B, PAP IB, REG III, Reg III-gamma)REG3G Antibody (YA7138) is a Mouse-derived and non-conjugated IgG1, Kappa monoclonal antibody, targeting to REG3G.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB, IHC-P, IHC-F, ICC/IF
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Reactivity :
Human
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Formulation:
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IHC-F
IHC-F: Immunohistochemistry-Frozen
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|---|
| Dilution Ratio | 1:500-1000 | 1:100-500 | 1:100-500 | 1:100-500 |
Product Details
REG3G Antibody (YA7138) is a Mouse-derived and non-conjugated IgG1, Kappa monoclonal antibody, targeting to REG3G.
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Host Mouse
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Clonality Monoclonal,Recombinant
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 17kDa;
Recombinant human REG3G.
Endogenous
affinity purified by Protein G
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
REG3G is a Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota|Acts as a hormone in response to different stimuli like anti-inflammatory signals, such as IL17A, or gut microbiome. Is secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways. Induced by IL17A in keratinocytes, regulates keratinocyte proliferation and differentiation after skin injury. In parallel, inhibits skin inflammation through the inhibition of inflammatory cytokines such as IL6 and TNF. Induced by IL22 in lung epithelial cells, inhibits cytokine production and regulates allergic airway inflammation. Induced in small intestine by inulin-enriched diet and Lactobacillus gasseri enriched microbiome, plays a role in the improvement of gut barrier function, the regulation of energy balance and glucose levels. Modulates microbiota composition in duodenal contents. Produced by nociceptor in response to endotoxins, prevents endotoxic death by targeting kynurenine pathway in microglia|Has bacteriostatic activity|Has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus
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Subcellular Localization
Secreted,Cytoplasm
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Expression
Tissue_Specificity: Predominantly expressed in pancreas, where it may be restricted to exocrine pancreas. Moderate expression levels in testis and weak in heart, kidney and placenta -
Isoforms & Post-Translational Modification
Q6UW15 has two isomers: Q6UW15-1: 19330 Da (predicted); Q6UW15-2: 14409 Da (predicted).
Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity -
Subunit
Forms a hexameric membrane-permeabilizing oligomeric pore on membrane phospholipids
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SwissProt ID
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Synonyms
PAP1B, UNQ429/PRO162, REG3G, Regenerating islet-derived protein 3-gamma, REG-3-gamma, Pancreatitis-associated protein 1B, Pancreatitis-associated protein IB, Regenerating islet-derived protein III-gamma, PAP-1B, PAP IB, REG III, Reg III-gamma
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