RIC8A (RIC8) Antibody (YA7939)
(Synonyms: RIC8)RIC8A (RIC8) Antibody (YA7939) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RIC8A (RIC8).
-
Host:
Mouse
-
Isotype:
IgG1
-
Application:
IHC-P, ICC/IF
-
Reactivity :
Human, Mouse, Rat
-
Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:50-250 | 1:100-250 |
Product Details
RIC8A (RIC8) Antibody (YA7939) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RIC8A (RIC8).
-
Host Mouse
-
Clonality Monoclonal
-
Species ReactivityHuman, Mouse, Rat
-
Calculated Molecular Weight Predicted band size: 59.6 kDa
Full length human recombinant protein of human RIC8A produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
-
Appearance
Liquid
-
Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
RIC8A is a Chaperone that specifically binds and folds nascent G alpha proteins prior to G protein heterotrimer formation, promoting their stability and activity: folds GNAI1, GNAO1, GNA13 and GNAQ. Does not fold G(s) G-alpha proteins GNAS nor GNAL. Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (GNAI1), possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation[1].
-
Subcellular Localization
Cytoplasm, cell cortex,Cytoplasm
-
Isoforms & Post-Translational Modification
Q9NPQ8 has four isomers: Q9NPQ8-1: 59710 Da (predicted); Q9NPQ8-2: 58943 Da (predicted); Q9NPQ8-3: 60372 Da (predicted); Q9NPQ8-4: 59612 Da (predicted).
Phosphorylated at Ser-436 and Thr-441 by CK2, stabilizing its interface with G alpha proteins -
Subunit
Interacts with GDP-bound G alpha proteins GNAI1, GNAO1 and GNAQ, and with GNA13 with lower affinity (By similarity)
-
SwissProt ID
-
Synonyms
RIC8
Documentation
Powered by Bioz
