Semaphorin 7A Antibody (YA3554)(PBS only)
(Synonyms: SEMA7A; JMH; SEMAL; CDw108; SEMAK1; H-Sema-L; H-SEMA-K1; CD108 antibody)Semaphorin 7A Antibody (YA3554) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Semaphorin 7A.
-
Host:
Mouse
-
Isotype:
IgG1
-
Application:
WB, ELISA
-
Reactivity :
Human
-
Formulation:
Supplied in PBS, pH 7.4.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
|
|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:10000 |
Product Details
Semaphorin 7A Antibody (YA3554) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Semaphorin 7A.
-
Host Mouse
-
Species ReactivityHuman
-
Observed Molecular WeightObserved band size: 75 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 75 kDa
Purified recombinant fragment of human ZAP70 (AA: 169-390) expressed in E. Coli.
affinity purified.
Non-conjugated
IgG1
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in PBS, pH 7.4.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
Semaphorin 7A plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of pro-inflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes
-
Subcellular Localization
Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side
-
Expression
Tissue_specificity:Protein levels were detected in keratinocytes and vascular endothelial cells of the skin. It was also expressed in fibroblasts, keratinocytes, melanocytes, placenta, testes, ovaries, spleen, brain, spinal cord, lungs, heart, adrenal glands, lymph nodes, thymus, intestines, and kidneys.
Induction:Up-regulated in UV-irradiated fibroblasts, but not in UV-irradiated keratinocytes -
Isoforms & Post-Translational Modification
O75326 has 2 isomers: O75326-1: 74824 Da (predicted); O75326-2: 73364 Da (predicted).
-
Subunit
Interacts with ITGA1 and ITGB1 (Probable). Interacts with PLXNC1
-
SwissProt ID
-
Synonyms
SEMA7A; JMH; SEMAL; CDw108; SEMAK1; H-Sema-L; H-SEMA-K1; CD108 antibody
Documentation
Powered by Bioz
