Stathmin 1 Antibody (YA5629)
(Synonyms: C1orf215; Lag; LAP 18; LAP18; Leukemia associated phosphoprotein p18; Leukemia-associated phosphoprotein p18; Metablastin; Oncoprotein 18; OP 18; Op18; p18; p19; Phosphoprotein 19; Phosphoprotein p19; pp17; pp19; PR22; Pr22 protein; Prosolin; Protein Pr22; SMN; Stathmin; Stathmin1; STMN 1; Stmn1; STMN1_HUMAN)Stathmin 1 Antibody (YA5629) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Stathmin 1.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
IHC-P, WB, ICC/IF, ELISA
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|
| Dilution Ratio | 1:200-1000 | 1:500-2000 | 1:100-500 | 1:1000-5000 |
Product Details
Stathmin 1 Antibody (YA5629) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Stathmin 1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 17 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 17 kDa
Synthesized peptide derived from human Stathmin AA range: 1-100
Protein G
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Stathmin 1 is involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear
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Subcellular Localization
Cytoplasm, cytoskeleton
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Expression
Tissue_specificity:It is widely distributed. The strongest expression is found in the brain, spinal cord, and cerebellum, followed by the thymus, bone marrow, testes, and fetal liver. Moderate expression is found in the colon, ovaries, placenta, uterus, and trachea. It is detectable in all other tissues examined, but at significantly reduced levels. The lowest expression is found in the liver.
Induction:Down-regulated in response to enterovirus 71 (EV71) infection (at protein level) -
Isoforms & Post-Translational Modification
P16949 has 2 isomers: P16949-1: 17303 Da (predicted); P16949-2: 19824 Da (predicted).
Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity). Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity -
Subunit
Binds to two alpha/beta-tubulin heterodimers. Interacts with KIST
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SwissProt ID
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Synonyms
C1orf215; Lag; LAP 18; LAP18; Leukemia associated phosphoprotein p18; Leukemia-associated phosphoprotein p18; Metablastin; Oncoprotein 18; OP 18; Op18; p18; p19; Phosphoprotein 19; Phosphoprotein p19; pp17; pp19; PR22; Pr22 protein; Prosolin; Protein Pr22; SMN; Stathmin; Stathmin1; STMN 1; Stmn1; STMN1_HUMAN
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