TNFAIP8 Antibody
(Synonyms: TNFAIP8, TNF Alpha Induced Protein 8, MDC-3.13, SCC-S2, GG2-1, Head And Neck Tumor And Metastasis-Related Protein, Tumor Necrosis Factor Alpha-Induced Protein 8, NF-Kappa-B-Inducible DED-Containing Protein, TNF-Induced Protein GG2-1, NDED)TNFAIP8 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to TNFAIP8.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4) containing 30% glycerol, 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:500-1000 | 1:100-200 | 1:100-500 |
Product Details
TNFAIP8 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to TNFAIP8.
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Host Rabbit
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 23 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 23 kDa
A synthesized peptide derived from human SCC-S2
affinity purified.
Non-conjugated
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4) containing 30% glycerol, 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
TNFAIP8 acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation
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Subcellular Localization
Cytoplasm
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Expression
Tissue_Specificity: Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle.
Induction: By nuclear factor-KB (NF-KB) and TNF. Induction by TNF depends upon activation of NF-KB. -
Isoforms & Post-Translational Modification
TNFAIP8 has 4 isoforms, O95379-1: amino acid length is 198, molecular weight is 23003 Da (predicted); O95379-2: amino acid length is 190, molecular weight is 22048 Da (predicted); O95379-3: amino acid length is 188, molecular weight is 21877 Da (predicted); O95379-4: amino acid length is 210, molecular weight is 24385 Da (predicted).
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SwissProt ID
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Synonyms
TNFAIP8, TNF Alpha Induced Protein 8, MDC-3.13, SCC-S2, GG2-1, Head And Neck Tumor And Metastasis-Related Protein, Tumor Necrosis Factor Alpha-Induced Protein 8, NF-Kappa-B-Inducible DED-Containing Protein, TNF-Induced Protein GG2-1, NDED
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