Topoisomerase 2 beta Antibody
(Synonyms: DNA topoisomerase 2-beta, TOP2B)Topoisomerase 2 beta Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Topoisomerase 2 beta.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF, ChIP
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Reactivity :
Human, Mouse, Dog
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ChIP
ChIP: Chromatin Immunoprecipitation
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|---|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 | 1:50-200 | 1:10-100 |
Product Details
Topoisomerase 2 beta Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Topoisomerase 2 beta.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Dog
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Observed Molecular WeightObserved band size: 183 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 183 kDa
Synthetic peptide corresponding to the N-term region of human Topoisomerase 2 beta.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Topoisomerase 2 beta is key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation
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Subcellular Localization
Nucleus, nucleolus; Nucleus, nucleoplasm; Nucleus
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Expression
Tissue_Specificity: Expressed in the tonsil, spleen, lymph node, thymus, skin, pancreas, testis, colon, kidney, liver, brain and lung. Also found in breast, colon and lung carcinomas, Hodgkin's disease, large-cell non-Hodgkin's lymphoma, lymphocytic lymphomas and seminomas. -
Isoforms & Post-Translational Modification
Topoisomerase 2 beta has 2 isoforms, Q02880-1: amino acid length is 1626, molecular weight is 183267 Da (predicted); Q02880-2: amino acid length is 1621, molecular weight is 182663 Da (predicted).
(Microbial infection) Deubiquitinated by Epstein-Barr virus BPLF1; leading to stabilized SUMOylated TOP2A trapped in cleavage complexes, which halts the DNA damage response to TOP2A-induced double-strand DNA breaks. -
Subunit
Homodimer.
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SwissProt ID
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Synonyms
DNA topoisomerase 2-beta, TOP2B
Documentation
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