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TRIP13 Antibody (YA7779)

(Synonyms: 16E1BP)
Customer Review

Based on 1 Customer Validation

TRIP13 Antibody (YA7779) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TRIP13.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    WB, IHC-P

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

  • Conjugation:
    Non-conjugated
  • Experimental Validation Results for TRIP13 Antibody (YA7779)
  • TRIP13 Antibody (YA7779) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:500-2000 1:2000-2500

Product Details

Description

TRIP13 Antibody (YA7779) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TRIP13.

  • Host Mouse
  • Clonality Monoclonal
  • Species Reactivity
    Human, Mouse, Rat
Immunogen

Human recombinant protein fragment corresponding to amino acids 31-148 of human TRIP13 produced in E.coli.

Sensitivity

Endogenous

Purification

Affinity purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Verification Images

  • Experimental Validation Results for TRIP13 Antibody (YA7779)
    Western blot analysis of extracts from Hela(lane 2(20μg) , HEK293(lane 3(20μg) ,Jurkat(lane 4(20μg)and NIH/3T3( lane 5(20μg) using TRIP13 Antibody (HY-P88095). Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80993，1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse IgG-HRP Secondary Antibody (HY-P8004,1/10,000) was used for 1 hour at room temperature.

Background

  • Function

    TRIP13 plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes. Plays a role in mitotic spindle assembly checkpoint (SAC) activation[1].

  • Isoforms & Post-Translational Modification

    Q15645 has two isomers: Q15645-1: 48551 Da (predicted); Q15645-2: 22084 Da (predicted).

  • Subunit

    Specifically interacts with the ligand binding domain of the thyroid receptor (TR)

  • SwissProt ID

    Q15645

  • Synonyms

    16E1BP

TRIP13 Antibody (YA7779) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • 1/16

    MedChemExpress Validation
     Western blot analysis of extracts from Hela(lane 2(20μg) , HEK293(lane 3(20μg) ,Jurkat(lane 4(20μg)and NIH/3T3( lane 5(20μg) using TRIP13 Antibody (HY-P88095). Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80993，1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse IgG-HRP Secondary Antibody (HY-P8004,1/10,000) was used for 1 hour at room temperature.

  • TRIP13 Antibody (YA7779) Product Image
    1/16
  • Experimental Validation Results for TRIP13 Antibody (YA7779)
  • TRIP13 Antibody (YA7779) Product Image
  • Experimental Validation Results for TRIP13 Antibody (YA7779)
    1/1
    MedChemExpress Validation
     Western blot analysis of extracts from Hela(lane 2(20μg) , HEK293(lane 3(20μg) ,Jurkat(lane 4(20μg)and NIH/3T3( lane 5(20μg) using TRIP13 Antibody (HY-P88095). Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80993，1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse IgG-HRP Secondary Antibody (HY-P8004,1/10,000) was used for 1 hour at room temperature.
  • Experimental Validation Results for TRIP13 Antibody (YA7779)
  • TRIP13 Antibody (YA7779) Product Image
    MedChemExpress Validation

    Western blot analysis of extracts from Hela(lane 2(20μg) , HEK293(lane 3(20μg) ,Jurkat(lane 4(20μg)and NIH/3T3( lane 5(20μg) using TRIP13 Antibody (HY-P88095). Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80993，1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse IgG-HRP Secondary Antibody (HY-P8004,1/10,000) was used for 1 hour at room temperature.

  • TRIP13 Antibody (YA7779) Product Image WB