VEGFC Antibody
(Synonyms: Vascular endothelial growth factor C, VEGF-C, Flt4 ligand, Vascular endothelial growth factor-related protein, Flt4-L, VRP, VEGFC)VEGFC Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to VEGFC.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 |
Product Details
VEGFC Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to VEGFC.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 47 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 46 kDa
Synthetic peptide corresponding to the center region of human VEGFC.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
VEGFC is a Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors
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Subcellular Localization
Secreted
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Expression
Tissue_Specificity: Expressed in the spleen. Expressed in the lymph node, thymus, appendix and bone marrow. Expressed in the heart, placenta, skeletal muscle, ovary and small intestine. Expressed in the prostate, testis and colon. -
Isoforms & Post-Translational Modification
VEGFC has an amino acid length of 419, molecular weight is 46883 Da.经历复杂的蛋白水解成熟过程，产生多种加工后的分泌形式，对 VEGFR-3 的活性升高，但只有完全加工的形式才能激活 VEGFR-2。VEGF-C 首先形成通过二硫键连接的反平行同源二聚体。分泌前，第 227 位精氨酸(Arg-227)和第 228 位丝氨酸(Ser-228)之间发生切割，产生异四聚体。后续的胞外加工步骤会去除 N 端前肽。最终成熟的 VEGF-C 主要由两个通过非共价相互作用结合的 VEGF 同源结构域(VHD)组成VEGFC 的氨基酸个数为 419 个，分子量为 46883 Da。Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3, but only the fully processed form could activate VEGFR-2. VEGF-C first form an antiparallel homodimer linked by disulfide bonds. Before secretion, a cleavage occurs between Arg-227 and Ser-228 producing a heterotetramer. The next extracellular step of the processing removes the N-terminal propeptide. Finally the mature VEGF-C is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions
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Subunit
Homodimer; non-covalent and antiparallel.
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SwissProt ID
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Synonyms
Vascular endothelial growth factor C, VEGF-C, Flt4 ligand, Vascular endothelial growth factor-related protein, Flt4-L, VRP, VEGFC
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