WDR1 Antibody (YA2417)(PBS only)
(別名: AIP1; NORI-1; HEL-S-52)WDR1 Antibody (YA2417) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to WDR1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-F, IHC-P, ICC/IF
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IHC-F
IHC-F: Immunohistochemistry-Frozen
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:100 | 1:50-1:100 | 1:50-1:200 |
Product Details
WDR1 Antibody (YA2417) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to WDR1.
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Host Rabbit
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 66 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 66 kDa
A synthetic peptide of human WDR1 aa325-339.
Affinity Purified
Non-conjugated
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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輸送条件
Shipping with blue ice.
Background
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Function
Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458, PubMed:27557945, PubMed:29751004). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565)
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Subcellular Localization
Cytoplasm; Cytoplasm, cytoskeleton; Cell projection, podosome; Cell junction
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Expression
Tissue_specificity:Expressed in peripheral blood mononuclear cells (at protein level) -
Isoforms & Post-Translational Modification
O75083 has 2 isomers: O75083-1: 66194 Da (predicted); O75083-3: 50694 Da (predicted).
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SwissProt ID
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別名
AIP1; NORI-1; HEL-S-52
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Research Field
Signal Transduction
ドキュメント
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