Anticancer agent 222

Cat. No.: HY-161648: Data Sheet Handling Instructions
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Anticancer agent 222 (Compound 19) is an orally active anticancer agent that exhibits significant anticancer activity against Huh7, FOCUS, SNU475, SNU182, HepG2, and Hep3B cells (IC₅₀ = 2.9–9.3 μM).

For research use only. We do not sell to patients.

Anticancer agent 222 Chemical Structure

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	10.8 μM Compound: 19	Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 38688437]
Hep 3B2	IC₅₀	10.3 μM Compound: 19	Cytotoxicity against human Hep3B cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Cytotoxicity against human Hep3B cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 38688437]
HepG2	IC₅₀	6.6 μM Compound: 19	Cytotoxicity against human HepG2 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Cytotoxicity against human HepG2 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 38688437]
Huh-7	IC₅₀	9.3 μM Compound: 19	Cytotoxicity against human Huh-7 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Cytotoxicity against human Huh-7 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 38688437]
MCF7	IC₅₀	6.1 μM Compound: 19	Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 38688437]
Mahlavu	IC₅₀	19.8 μM Compound: 19	Cytotoxicity against human Mahlavu cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Cytotoxicity against human Mahlavu cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 38688437]
PLC	IC₅₀	99.1 μM Compound: 19	Cytotoxicity against human PLC cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Cytotoxicity against human PLC cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 38688437]
SNU-182	IC₅₀	16.4 μM Compound: 19	Cytotoxicity against human SNU-182 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Cytotoxicity against human SNU-182 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 38688437]
SNU-387	IC₅₀	98.7 μM Compound: 19	Cytotoxicity against human SNU-387 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Cytotoxicity against human SNU-387 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 38688437]
SNU-398	IC₅₀	19 μM Compound: 19	Cytotoxicity against human SNU-398 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Cytotoxicity against human SNU-398 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 38688437]
SNU-423	IC₅₀	24.9 μM Compound: 19	Cytotoxicity against human SNU-423 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Cytotoxicity against human SNU-423 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 38688437]
SNU-449	IC₅₀	60.6 μM Compound: 19	Cytotoxicity against human SNU-449 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Cytotoxicity against human SNU-449 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 38688437]
SNU-475	IC₅₀	17 μM Compound: 19	Cytotoxicity against human SNU-475 cells assessed as cell growth inhibition by SRB assay Cytotoxicity against human SNU-475 cells assessed as cell growth inhibition by SRB assay	[PMID: 38688437]

Molecular Weight

560.54

Formula

C₂₈H₂₆F₆N₆

SMILES

FC(F)(F)C(C=C1)=CC=C1C2=NC3=C(N=CN=C3N2C4CCCC4)N(CC5)CCN5C6=CC=C(C(F)(F)F)C=C6

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Fatih Polat M, et al. Synthesis and cytotoxicity of novel 6,8,9-trisubstituted purine analogs against liver cancer cells. Bioorg Med Chem Lett. 2024;106:129775. [Content Brief]