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Cat. No.: HY-161648

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Anticancer agent 222

Anticancer agent 222 (Compound 19) is an orally active anticancer agent that exhibits significant anticancer activity against Huh7, FOCUS, SNU475, SNU182, HepG2, and Hep3B cells (IC₅₀ = 2.9–9.3 μM).

For research use only. We do not sell to patients.

Formula: C₂₈H₂₆F₆N₆
Molecular Weight:560.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Anticancer agent 222 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	10.8 μM Compound: 19	Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 38688437]
Hep 3B2	IC₅₀	10.3 μM Compound: 19	Cytotoxicity against human Hep3B cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Cytotoxicity against human Hep3B cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 38688437]
HepG2	IC₅₀	6.6 μM Compound: 19	Cytotoxicity against human HepG2 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Cytotoxicity against human HepG2 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 38688437]
Huh-7	IC₅₀	9.3 μM Compound: 19	Cytotoxicity against human Huh-7 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Cytotoxicity against human Huh-7 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 38688437]
Mahlavu	IC₅₀	19.8 μM Compound: 19	Cytotoxicity against human Mahlavu cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Cytotoxicity against human Mahlavu cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 38688437]
MCF7	IC₅₀	6.1 μM Compound: 19	Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 38688437]
PLC	IC₅₀	99.1 μM Compound: 19	Cytotoxicity against human PLC cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Cytotoxicity against human PLC cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 38688437]
SNU-182	IC₅₀	16.4 μM Compound: 19	Cytotoxicity against human SNU-182 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Cytotoxicity against human SNU-182 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 38688437]
SNU-387	IC₅₀	98.7 μM Compound: 19	Cytotoxicity against human SNU-387 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Cytotoxicity against human SNU-387 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 38688437]
SNU-398	IC₅₀	19 μM Compound: 19	Cytotoxicity against human SNU-398 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Cytotoxicity against human SNU-398 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 38688437]
SNU-423	IC₅₀	24.9 μM Compound: 19	Cytotoxicity against human SNU-423 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Cytotoxicity against human SNU-423 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 38688437]
SNU-449	IC₅₀	60.6 μM Compound: 19	Cytotoxicity against human SNU-449 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Cytotoxicity against human SNU-449 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 38688437]
SNU-475	IC₅₀	17 μM Compound: 19	Cytotoxicity against human SNU-475 cells assessed as cell growth inhibition by SRB assay Cytotoxicity against human SNU-475 cells assessed as cell growth inhibition by SRB assay	[PMID: 38688437]

Chemical Information

Molecular Weight 560.54
Formula C₂₈H₂₆F₆N₆
SMILES

FC(F)(F)C(C=C1)=CC=C1C2=NC3=C(N=CN=C3N2C4CCCC4)N(CC5)CCN5C6=CC=C(C(F)(F)F)C=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Fatih Polat M, et al. Synthesis and cytotoxicity of novel 6,8,9-trisubstituted purine analogs against liver cancer cells. Bioorg Med Chem Lett. 2024;106:129775. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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