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Cat. No.: HY-146406

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Anticancer agent 52

Anticancer agent 52 is a potent anticancer agent. Anticancer agent 52 shows in vitro cytotoxicity. Anticancer agent 52 induces apoptosis. Anticancer agent 52 shows antitumor effect. Anticancer agent 52 has the potential for the research of bladder cancer.

For research use only. We do not sell to patients.

CAS No.: 2388983-64-8
Formula: C₅₀H₄₃Br₂N₂P
Molecular Weight:862.67

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (282 KB)

Anticancer agent 52 Chemical Structure

CAS No.: 2388983-64-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
5637	GI₅₀	200 μM Compound: TPP1	Growth inhibition of human 5637 cells measured after 1 hr by Celltiter-Glo luminescent cell viability assay Growth inhibition of human 5637 cells measured after 1 hr by Celltiter-Glo luminescent cell viability assay	[PMID: 31718944]
RT-112	GI₅₀	200 μM Compound: TPP1	Growth inhibition of human RT112 cells measured after 1 hr by Celltiter-Glo luminescent cell viability assay Growth inhibition of human RT112 cells measured after 1 hr by Celltiter-Glo luminescent cell viability assay	[PMID: 31718944]
RT-4	GI₅₀	150 μM Compound: TPP1	Growth inhibition of human RT4 cells measured after 1 hr by Celltiter-Glo luminescent cell viability assay Growth inhibition of human RT4 cells measured after 1 hr by Celltiter-Glo luminescent cell viability assay	[PMID: 31718944]
SW780	GI₅₀	200 μM Compound: TPP1	Growth inhibition of human SW780 cells measured after 1 hr by Celltiter-Glo luminescent cell viability assay Growth inhibition of human SW780 cells measured after 1 hr by Celltiter-Glo luminescent cell viability assay	[PMID: 31718944]
TCC-SUP	GI₅₀	240 μM Compound: TPP1	Growth inhibition of human TCCSUP cells measured after 1 hr by Celltiter-Glo luminescent cell viability assay Growth inhibition of human TCCSUP cells measured after 1 hr by Celltiter-Glo luminescent cell viability assay	[PMID: 31718944]
UMUC3	GI₅₀	80 μM Compound: TPP1	Growth inhibition of human UM-UC-3 cells measured after 1 hr by Celltiter-Glo luminescent cell viability assay Growth inhibition of human UM-UC-3 cells measured after 1 hr by Celltiter-Glo luminescent cell viability assay	[PMID: 31718944]

In Vitro

Anticancer agent 52 (compound TPP1) (0-2048 µM) shows cytotoxicity with IC₅₀s of 200, 200, 150, 200, 240, 80 µM for 5637, RT112, RT4, SWT80, TCCSUP, UMUC3 cells, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

RT112 cells
Concentration:

200 µM
Incubation Time:

1, 2, 4 h
Result:

Induced apoptosis with the increased the expression of c-PARP.

Chemical Information

CAS No. 2388983-64-8
Molecular Weight 862.67
Formula C₅₀H₄₃Br₂N₂P
SMILES

C1([P+](C2=CC=CC=C2)(C3=CC=CC=C3)CCCC4=[N+](C5=C(N4CC6=CC7=C(C=C6)C=CC=C7)C=CC=C5)CC8=CC=C9C=CC=CC9=C8)=CC=CC=C1.[Br-].[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (282 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Stromyer ML, et al. Synthesis, characterization, and biological activity of a triphenylphosphonium-containing imidazolium salt against select bladder cancer cell lines. Eur J Med Chem. 2020 Jan 1;185:111832. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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