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Cat. No.: HY-155709

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Antifungal agent 67

Antifungal agent 67 (compound 9) is an imidazole antifungal agent that is effective against Candida. Antifungal agent 67 has a CC50 value of 33.6 μM on healthy neonatal rat cardiomyoblasts.

For research use only. We do not sell to patients.

CAS No.: 2925307-52-2
Formula: C₂₃H₂₅ClN₂O₃
Molecular Weight:412.91

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Antifungal agent 67 Chemical Structure

CAS No.: 2925307-52-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Antifungal agent 67 (compound 9) is an imidazole antifungal agent that is effective against Candida. Antifungal agent 67 has a CC50 value of 33.6 μM on healthy neonatal rat cardiomyoblasts^[1].

IC₅₀ & Target

monilia^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
H9c2	CC₅₀	33.6 μM Compound: 9	Cytotoxicity against H9c2 cells assessed as inhibition of cell proliferation incubated for 72 hrs by resazurin dye based microplate reader analysis Cytotoxicity against H9c2 cells assessed as inhibition of cell proliferation incubated for 72 hrs by resazurin dye based microplate reader analysis	[PMID: 37146343]

Chemical Information

CAS No. 2925307-52-2
Molecular Weight 412.91
Formula C₂₃H₂₅ClN₂O₃
SMILES

ClC1=CC=C(C=C1)COC(COC2=CC=C(CC=C)C=C2OC)CN3C=CN=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Campos Péret VA, et al. New miconazole-based azoles derived from eugenol show activity against Candida spp. and Cryptococcus gattii by inhibiting the fungal ergosterol biosynthesis. Eur J Med Chem. 2023 Aug 5;256:115436. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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