Antimicrobial peptide BP100
Antimicrobial peptide BP100 is a cecropin-α-melittin hybrid linear undecapeptide that exerts bactericidal activity against bacteria through non-specific, amphipathicity-driven membrane damage. Antimicrobial peptide BP100 exhibits in vitro antimicrobial activity against a variety of plant and human pathogens. Antimicrobial peptide BP100 can be used in studies related to bacterial infections, such as those involving phytopathogenic Gram-negative bacteria.
For research use only. We do not sell to patients.
- CAS No.: 1001644-68-3
- Formula: C72H125N17O12
- Molecular Weight:1420.87
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Antimicrobial peptide BP100 inhibits the growth of both colistin-sensitive and colistin-resistant Acinetobacter baumannii strains, with a MIC ranging from 8.5 μg/mL to 67 μg/mL. Furthermore, in colistin-enriched media, the peptide exhibits reduced activity against some resistant strains, and at a concentration of 150 μM, it induces 33% hemolysis[1].
Antimicrobial peptide BP100 inhibits growth of Erwinia amylovora PMV6076, Xanthomonas arboricola pv. pruni CFBP5563, Xanthomonas fragariae Xf349-9A, Xanthomonas axonopodis pv. vesicatoria 2133-2, Pseudomonas syringae pv. actinidiae Psa3700.1.1, and Pseudomonas syringae pv. syringae EPS94 with MIC values ranging from 1.6 to 6.2 μM, and its conjugation to plant defense elicitor peptides Pep13 or flg15 improves its antibacterial potency against these pathogens[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1001644-68-3
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Molecular Weight 1420.87
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Formula C72H125N17O12
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SMILES
OC(C=C1)=CC=C1C[C@@H](C(N[C@H](C(N)=O)CC(C)C)=O)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@H]([C@@H](C)CC)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@@H](N)CCCCN)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)=O
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Sequence
Lys-Lys-Leu-Phe-Lys-Lys-Ile-Leu-Lys-Tyr-Leu-NH2
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Sequence Shortening
KKLFKKILKYL-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antimicrobial peptide BP100 Related Classifications
HY-P12210 Related Classifications
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Keywords
- Antimicrobial peptide BP100
- 1001644-68-3
- Antimicrobial peptide BP 100
- Antimicrobial peptide BP-100
- Bacterial
- Drug Intermediate
- Erwinia amylovora
- pmrB
- Xanthomonas fragariae
- lpxC
- pmrA
- colistin-susceptible Acinetobacter baumannii strains
- Acinetobacter baumannii ATCC BAA-1605
- colistin-resistant Acinetobacter baumannii strains
- Xanthomonas arboricola pv. pruni
- Xanthomonas axonopodis pv. vesicatoria
- Inhibitor
- inhibitor
- inhibit