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Cat. No.: HY-N12414

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Apicularen A

Apicularen A is a macrolide isolated from the mucoid bacterium Chondrosporium spp. Apicularen A is also a highly selective inhibitor of vesicular ATPase.

For research use only. We do not sell to patients.

CAS No.: 220757-04-0
Formula: C₂₅H₃₁NO₆
Molecular Weight:441.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Apicularen A Chemical Structure

CAS No.: 220757-04-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Apicularen A is a macrolide isolated from the mucoid bacterium Chondrosporium spp. Apicularen A is also a highly selective inhibitor of vesicular ATPase^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
1A9	IC₅₀	0.78 nM Compound: 254 (Apicularen A)	Cytotoxicity against 1A9 human ovarian carcinoma cells Cytotoxicity against 1A9 human ovarian carcinoma cells	[PMID: 16134928]

Chemical Information

CAS No. 220757-04-0
Molecular Weight 441.52
Formula C₂₅H₃₁NO₆
SMILES

O=C(O1)C(C(C[C@](C[C@H]2O)([H])O[C@@](C2)([H])C[C@@H]1C/C=C/NC(/C=C\C=C/CC)=O)=CC=C3)=C3O
Structure Classification
- Others
Initial Source
- Microorganisms
Chondromyces
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. B Kunze, et al. Apicularens A and B, new cytostatic macrolides from Chondromyces species (myxobacteria): production, physico-chemical and biological properties. J Antibiot (Tokyo). 1998 Dec;51(12):1075-80. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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