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Cat. No.: HY-W109136

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AR-V7 ligand-13

AR-V7 ligand-13 is a ligand of AR-V7 and can be used in PROTAC synthesis-related research, such as PROTAC AR-V7 degrader-16 (HY-190936).

For research use only. We do not sell to patients.

CAS No.: 1621375-40-3
Formula: C₁₃H₁₂F₂N₂O₂S
Molecular Weight:298.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

AR-V7 ligand-13 Chemical Structure

CAS No.: 1621375-40-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

AR-V7 ligand-13 is a ligand of AR-V7 and can be used in PROTAC synthesis-related research, such as PROTAC AR-V7 degrader-16 (HY-190936)^[1].

IC₅₀ & Target

^[1]

AR-V7

Cellular Effect

Cell Line	Type	Value	Description	References
LNCaP	IC₅₀	0.7 μM Compound: 33	Inhibition of androgen receptor in human LNCaP cells assessed as inhibition of prostate-specific antigen secretion into media after 3 days Inhibition of androgen receptor in human LNCaP cells assessed as inhibition of prostate-specific antigen secretion into media after 3 days	[PMID: 25062331]
LNCaP	IC₅₀	0.8 μM Compound: 33	Inhibition of androgen receptor transcriptional activity in human LNCaP cells after 3 days by eGFP assay Inhibition of androgen receptor transcriptional activity in human LNCaP cells after 3 days by eGFP assay	[PMID: 25062331]

In Vitro

AR-V7 ligand-13 (ARB-1) serves as the target protein ligand for PROTAC AR-V7 degrader-16 (HY-190936), and PROTAC AR-V7 degrader-16 is a PROTAC molecule targeting AR^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1621375-40-3
Molecular Weight 298.31
Formula C₁₃H₁₂F₂N₂O₂S
SMILES

OC1=C(C2=CSC(N3CCOCC3)=N2)C=CC(F)=C1F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Desantis J, et al. Bi-functional compounds and methods for targeted ubiquitination of androgen receptor. WO2023039604A1, 2023.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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