Art. -Nr.: HY-110288

3FAx-Neu5Ac

Name: 3FAx-Neu5Ac
Brand: MedChemExpress
SKU: HY-110288
Price: 160.00 USD
Availability: InStock
Rating: 5 (5 reviews)

5 Cited Publications

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Based on 5 publication(s) in Google Scholar

3FAx-Neu5Ac (Compound 8), a Sialic acid peracetylated analog, is a sialyltransferase inhibitor. 3FAx-Neu5Ac substantially reduces expression of the sialylated ligand sialyl Lewis X.

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Reinheit : 99.88%
CAS. Nr.: 117405-58-0
Formel: C₂₂H₃₀FNO₁₄
Molecular Weight:551.47

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

3FAx-Neu5Ac Chemical Structure

CAS. Nr.: 117405-58-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Publications (5)
Lösungsmittel & Löslichkeit
- In Vitro
Protokoll (1)
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

3FAx-Neu5Ac (Compound 8), a Sialic acid peracetylated analog, is a sialyltransferase inhibitor. 3FAx-Neu5Ac substantially reduces expression of the sialylated ligand sialyl Lewis X^[1].

In Vitro

3FAx-Neu5Ac (300 μM, 7 days) reduces sialylation on HECA-452 MM1S cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS. Nr. 117405-58-0
Appearance Solid
Molecular Weight 551.47
Formel C₂₂H₃₀FNO₁₄
Color White to off-white
SMILES

COC([C@]1(O[C@@]([C@H](NC(C)=O)[C@@H](OC(C)=O)[C@H]1F)([H])[C@H](OC(C)=O)[C@H](OC(C)=O)COC(C)=O)OC(C)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (5)

All Flow CytometryBio/Physico-chemical AssayCell Imaging/StainingWB

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Journal Impact Factor

Research (Wash D C)

Small-Molecule Boron-10-Enriched Carriers with Exceptional Aqueous Solubility for Enhanced Boron Neutron Capture Therapy of Malignant Tumors. [Abstract]

2026 Jul 3:9:1315. PMID: 42404354
NPJ Breast Cancer

CD52 signaling via macrophage Siglec-G represents a therapeutic target for cancer immunotherapy. [Abstract]

2026 Jan 24;12(1):29. PMID: 41580422

3FAx-Neu5Ac purchased from MedChemExpress. Usage Cited in: NPJ Breast Cancer. 2026 Jan 24;12(1):29. [Abstract]

Macrophage phagocytosis of 4T1 cells pretreated with PBS control or sialic acid inhibitor 3FAx-Neu5Ac (100 μM; 24 h). 3FAx-Neu5Ac mediated sialic acid removal in 4T1 cells remarkably enhanced macrophage phagocytosis of tumor cells.
Food Funct

Theabrownin derived from Pu-erh tea enhances intestinal barrier integrity and microbiota balance via the ST6GalNAc6-STn-MUC2 axis in inflammation. [Abstract]

2026 Apr 27. PMID: 42037092
bioRxiv

2025 Aug 08.

3FAx-Neu5Ac purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Aug 08.

3FAX-Neu5Ac (0-200 μM; 24 h) inhibited sialic acid modification in HCT116 cells in a dose-dependent manner.
bioRxiv

2025 June 02.

3FAx-Neu5Ac purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 June 02.

Fluorescent microscopy of lectin binding in 3FAx-Neu5Ac-treated WT MDBK cells. 3Fax-Neu5Ac (200 μM; 10 d) effectively depleted α2,3/α2,6-linked sialic acids in MDBK cells.

3FAx-Neu5Ac purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 June 02.

MDBK cells were treated with either DMSO or 3FAx-Neu5Ac (200 μM; 10 d) and subsequently infected with BPIV3 at a MOI of 1. After 24 hours, The levels of viral nucleoprotein (NP) replication within the cells were assessed as a measure of infection.

3FAx-Neu5Ac purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 June 02.

Primary bovine nasal turbinate cells were isolated and treated with 3Fax-Neu5Ac (200 μM; 10 d) to investigate the distribution of sialic acids. A significant reduction in cell surface sialic acid levels was observed following treatment with the 3Fax-Neu5Ac inhibitor.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (181.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.8133 mL

9.0667 mL

18.1334 mL

5 mM

0.3627 mL

1.8133 mL

3.6267 mL

10 mM

0.1813 mL

0.9067 mL

1.8133 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Protokoll

All Molecular Biology

RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Cory D Rillahan, et al. Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome. Nat Chem Biol. 2012 Jul;8(7):661-8. [Content Brief]

[2]. Natoni A, et al. Inhibition of Sialylation Impairs Adhesion on Madcam-1 and E-Selectin and Sensitize Multiple Myeloma Cells to Bortezomib in a Xenograft Mouse Model. Blood, 2018, 132: 3204.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.8133 mL	9.0667 mL	18.1334 mL	45.3334 mL
	5 mM	0.3627 mL	1.8133 mL	3.6267 mL	9.0667 mL
	10 mM	0.1813 mL	0.9067 mL	1.8133 mL	4.5333 mL
	15 mM	0.1209 mL	0.6044 mL	1.2089 mL	3.0222 mL
	20 mM	0.0907 mL	0.4533 mL	0.9067 mL	2.2667 mL
	25 mM	0.0725 mL	0.3627 mL	0.7253 mL	1.8133 mL
	30 mM	0.0604 mL	0.3022 mL	0.6044 mL	1.5111 mL
	40 mM	0.0453 mL	0.2267 mL	0.4533 mL	1.1333 mL
	50 mM	0.0363 mL	0.1813 mL	0.3627 mL	0.9067 mL
	60 mM	0.0302 mL	0.1511 mL	0.3022 mL	0.7556 mL
	80 mM	0.0227 mL	0.1133 mL	0.2267 mL	0.5667 mL
	100 mM	0.0181 mL	0.0907 mL	0.1813 mL	0.4533 mL

Bioz

Keywords

3FAx-Neu5Ac

5 Cited Publications

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3FAx-Neu5Ac

Publications Citing Use of MedChemExpress (MCE) 3FAx-Neu5Ac