AD 0261
AD 0261 is a radical scavenger which displays strong inhibitory action on the generation of lipid peroxides and superoxide anions.
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- CAS. Nr.: 145600-69-7
- Formel: C27H31F2N3O
- Molecular Weight:451.55
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
AD 0261 displays strong inhibitory action on the generation of lipid peroxides (IC50=0.022 μM) and superoxide anions (IC50= 0.9-4.0 μM). AD 0261 inhibits cytokine release and/or production from PHA-P-stimulated lymphocytes in a dose-dependent manner. AD 0261 inhibits all parameters which are indicative of lymphocyte activation with 50% inhibition being achieved in a range of 1-10 μM. AD 0261 suppresses ornithine decarboxylase activity, the IC50 value being around 1.0 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 145600-69-7
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Molecular Weight 451.55
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Formel C27H31F2N3O
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SMILES
OC1=CC=C(C)C=C1NCCCN2CCN(C(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)CC2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
For measurement of [3H]TdR incorporation, cells are incubated for 16 h and additional (6 h) incubation is carried out in the presence of [3H]TdR (0.5 μCi/well). [3H]TdR incorporation is evaluated in a liquid scintillation counter. IL-2 release from lymphocytes is estimated after 20 h incubation by enzyme immunoassay using the commercially available kits. IL-2 receptor expression is quantitated by flow-cytometry using an FITC-labelled monoclonal antibody which recognizes achain of IL-2 receptor complex. Cell viability is determined by either trypan blue exclusion test or propidium iodide staining.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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