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Art. -Nr.: HY-13320

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2-Keto Crizotinib

Name: 2-Keto Crizotinib
Brand: MedChemExpress
SKU: HY-13320
Price: 668.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: PF-06260182)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

2-Keto Crizotinib (PF-06260182) is an active lactam metabolite of crizotinib.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 1415558-82-5
Formel: C₂₁H₂₀Cl₂FN₅O₂
Molecular Weight:464.32

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

2-Keto Crizotinib Chemical Structure

CAS. Nr.: 1415558-82-5

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Publications (1)
Reinheit & Dokumentation
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Calculators
Help & FAQs
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Biologische Aktivität

Beschreibung

2-Keto Crizotinib (PF-06260182) is an active lactam metabolite of crizotinib.

In Vitro

2-Keto Crizotinib (PF-06260182) is active and considerably less potent than crizotinib, and it is not thought to contribute significantly to the in vivo activity of crizotinib.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1415558-82-5
Molecular Weight 464.32
Formel C₂₁H₂₀Cl₂FN₅O₂
SMILES

O=C1CC(N2N=CC(C3=CC(O[C@H](C)C4=C(Cl)C(F)=CC=C4Cl)=C(N)N=C3)=C2)CCN1
Synonyms

PF-06260182
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Gene

Selenoprotein S regulates tumorigenesis of clear cell renal cell carcinoma through AKT/ GSK3β/NF-κB signaling pathway. [Abstract]

2022 Jul 20;832:146559. PMID: 35569765

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Balis FM, e al. First-dose and steady-state pharmacokinetics of orally administered crizotinib in children with solid tumors: a report on ADVL0912 from the Children's Oncology Group Phase 1/Pilot Consortium. Cancer Chemother Pharmacol. 2017 Jan;79(1):181- [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

2-Keto Crizotinib

1 Cited Publications

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Biologische Aktivität
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Chemical Information
Publications (1)
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2-Keto Crizotinib

Publications Citing Use of MedChemExpress (MCE) 2-Keto Crizotinib