ACT-007
ACT-007 is an indolocarbazole alkaloid derived from Actinomadura sp., which selectively inhibits the proliferation of lung cancer cells and induces G2/M phase cell cycle arrest in breast cancer cells. ACT-007 can be applied in the research of lung cancer and breast cancer.
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- CAS. Nr.: 866554-59-8
- Formel: C28H22N4O4
- Molecular Weight:478.50
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MV4-11 | IC50 |
> 1000 nM
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Antiproliferative activity against human acute myeloid leukemia MV4-11 cells assessed by CCK-8 assay.
Antiproliferative activity against human acute myeloid leukemia MV4-11 cells assessed by CCK-8 assay.
|
42565614 |
| MCF7 | IC50 |
> 1000 nM
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Antiproliferative activity against human breast cancer MCF-7 cells assessed by CCK-8 assay.
Antiproliferative activity against human breast cancer MCF-7 cells assessed by CCK-8 assay.
|
42565614 |
| MKN-45 | IC50 |
> 1000 nM
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Antiproliferative activity against human gastric cancer MKN-45 cells assessed by CCK-8 assay.
Antiproliferative activity against human gastric cancer MKN-45 cells assessed by CCK-8 assay.
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42565614 |
| HCT-116 | IC50 |
> 1000 nM
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Antiproliferative activity against human colorectal cancer HCT-116 cells assessed by CCK-8 assay.
Antiproliferative activity against human colorectal cancer HCT-116 cells assessed by CCK-8 assay.
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42565614 |
| 5637 | IC50 |
> 1000 nM
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Antiproliferative activity against human bladder carcinoma 5637 cells assessed by CCK-8 assay.
Antiproliferative activity against human bladder carcinoma 5637 cells assessed by CCK-8 assay.
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42565614 |
In Vitro
ACT-007 (compound 2) induces cell cycle arrest at the G2/M phase in temperature-sensitive mouse breast cancer tsFT210 cells[1].
ACT-007 selectively inhibits the proliferation of human lung cancer A549 cells[1].
ACT-007 does not exhibit significant antiproliferative activity against human acute myeloid leukemia MV4-11 cells, human breast cancer MCF-7 cells, human gastric cancer MKN-45 cells, human colorectal cancer HCT-116 cells, and human bladder cancer 5637 cells, with its IC50 value exceeding 1000 nM[1].
ACT-007 (0.0001-10 μM; 48 h) exhibits no antiproliferative activity against HCT-116, 5637, MKN-45, MV-4-11, or MCF-7 human cancer cell lines, with IC50 values > 1000 nM across all tested cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT-116, 5637, MKN-45, MV-4-11, MCF-7
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Concentration:0.0001, 0.001, 0.01, 0.1, 1, 5, 10 μM
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Incubation Time:48 h
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Result:Showed no antiproliferative activity against all tested human cancer cell lines, with IC50 values greater than 1000 nM for HCT-116, 5637, MKN-45, MV-4-11, and MCF-7 cells.
Chemical Information
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CAS. Nr. 866554-59-8
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Molecular Weight 478.50
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Formel C28H22N4O4
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SMILES
O=C1NCC2=C1C3=C4C5=C2C6=CC=CC=C6N5[C@@](C)(O7)[C@H](OC(N8C)=O)[C@H]8C[C@@H]7N4C9=C3C=CC=C9
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Synonyms
ZHD 0501
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
ACT-007 Related Classifications
HY-189002 Related Classifications
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