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Art. -Nr.: HY-187615

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AM4299 A

AM4299 A is a thiol protease inhibitor with IC₅₀ values of 73, 390 and 88 nM against Cathepsin B, Cathepsin L and Papain, respectively. AM4299 A shows low toxicity and favorable biosafety in mice. AM4299 A can be used in studies related to osteoporosis and parasitic diseases.

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CAS. Nr.: 160825-48-9
Formel: C₁₅H₂₆N₂O₆
Molecular Weight:330.38

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

AM4299 A Chemical Structure

CAS. Nr.: 160825-48-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Protokoll (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

Cathepsin C

73 nM (IC₅₀)

cathepsin L

390 nM (IC₅₀)

papain

88 nM (IC₅₀)

Alle Cathepsin Isoform-spezifische Produkte anzeigen :

In Vitro

AM4299 A specifically inhibits purified bovine spleen cathepsin B (IC₅₀ = 7.3 × 10^-8 M), human kidney cathepsin L (IC₅₀ = 3.9 × 10^-7 M), and Carica papaya papain (IC₅₀ = 8.8 × 10^-8 M), with no activity against bovine pancreas trypsin or α-chymotrypsin at concentrations up to 8.0 × 10^-5 M^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

In Vivo

AM4299 A (intravenous injection; 200 mg/kg) causes no mortality and exhibits low acute toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 160825-48-9
Molecular Weight 330.38
Formel C₁₅H₂₆N₂O₆
SMILES

C(N[C@H](C(NCCCCCO)=O)CC(C)C)(=O)C1C(C(O)=O)O1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Morishita A, et al. AM4299 A and B, novel thiol protease inhibitors[J]. The Journal of Antibiotics, 1994, 47(9): 1065-1068.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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