country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-126017

Copy Link Print Information

Aminopyridine 2

Aminopyridine 2 is an irreversible, selective, and orally active myeloperoxidase (MPO) inhibitor, with an IC₅₀ of 0.16 μM and a K_i of 24 μM against human MPO. Aminopyridine 2 is applicable to research on chronic inflammatory diseases.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 2411643-58-6
Formel: C₁₃H₁₃BrN₄O
Molecular Weight:321.18

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Aminopyridine 2 Chemical Structure

CAS. Nr.: 2411643-58-6

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Protokoll (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Glutathione Peroxidase Isoform-spezifische Produkte anzeigen :

GPX1
GPX4

In Vitro

Aminopyridine 2 (2 h) inhibits the activity of human MPO in plasma, with an apparent IC₅₀ of 1.9 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Parmacokinetics

Species	Dose	Route	C_max	T_max	AUC_0-∞	Bioavailability
Mice^[1]	10 mg/kg	p.o.	11884 nM	1.3 h	58440 nM·h/mL	51 %
Rat^[1]	10 mg/kg	p.o.	20844 nM	0.4 h	133162 nM·h/mL	~100 %
Dog^[1]	10 mg/kg	p.o.	19486 nM	2.3 h	335615 nM·h/mL	~100 %

In Vivo

Aminopyridine 2 (2.5-100 mg/kg; p.o.; single administration) dose-dependently inhibits MPO activity in a mouse peritonitis model^[1].
Aminopyridine 2 (~50-200 mg/kg; mixed with diet for 14 days) dose-dependently inhibits MPO activity in a mouse peritonitis model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J (male, 8 weeks old)^[1]
Dosage:

2.5 mg/kg; 25 mg/kg; 50 mg/kg; 100 mg/kg
Administration:

i.g.; single dose
Result:

Reduced residual plasma MPO activity by 24% at 2.5 mg/kg, 62% at 25 mg/kg, 74% at 50 mg/kg, and 86% at 100 mg/kg, measured 5 hours post-dose.
Caused dose-dependent inhibition of 3-chlorotyrosine accumulation in peritoneal exudate.
Achieved an apparent in vivo IC₅₀ of 1.4 μM for inhibition of plasma MPO activity.

Chemical Information

CAS. Nr. 2411643-58-6
Molecular Weight 321.18
Formel C₁₃H₁₃BrN₄O
SMILES

O=C(NC1=CC=C(Br)C=C1)NCC2=CN=C(N)C=C2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Marro ML, et al. Discovery of 1-((6-Aminopyridin-3-yl)Methyl)-3-(4-Bromophenyl)Urea as a Potent, Irreversible Myeloperoxidase Inhibitor. J Pharmacol Exp Ther. 2018;367(1):147-154. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen