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Art. -Nr.: HY-174820

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AZ'320

AZ'320 is an ATP-competitive necroptosis (EC₅₀ of 4.9 μM) inhibitor and a RIPK1 (pK_D of 5.45) inhibitor. AZ'320 inhibits necroptosis by inhibiting RIPK1 phosphorylation. AZ’320 prevents mortality of the mice and rescues temperature and body weight in SIRS mice models. AZ'320 can be used for researches of cancer and inflammation.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₀H₂₀N₂O₄S₂
Molecular Weight:416.51

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

AZ'320 Chemical Structure

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Preis

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle RIP kinase Isoform-spezifische Produkte anzeigen :

In Vitro

AZ’320 (0.1-10 μM, 4 h) dose-dependently inhibits the levels of RIPK1 Ser166 phosphorylation in I2.1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

I2.1 FADD^−/− human Jurkat cells
Concentration:

01, 1, 5 and 10 μM
Incubation Time:

4 h
Result:

Dose-dependently inhibited the levels of RIPK1 Ser166 phosphorylation.

In Vivo

AZ’320 (5 mg/kg, i.v., 15 min before TNF stimulation) prevents mortality of the mice and rescues temperature and body weight to a similar degree as Nec-1 (HY-15760) in SIRS mice models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Systemic inflammatory response syndrome (SIRS) mice models (C57BL/6, male, 6-8 weeks)^[1]
Dosage:

5 mg/kg
Administration:

Intravenously injection, 15 min before 96 h of 0.5 mg/kg TNF stimulation
Result:

Prevented mortality of the mice and rescued temperature and body weight to a similar degree as Nec-1 (HY-15760).

Chemical Information

Molecular Weight 416.51
Formel C₂₀H₂₀N₂O₄S₂
SMILES

O=S(C1=CC=C(C2=CC=C3C=CC=NC3=C2)C=C1)(N4CC(CS(=O)(C)=O)C4)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Soday L, et al. Discovery and Validation of a Novel Class of Necroptosis Inhibitors Targeting RIPK1. ACS Chem Biol. 2025 Jun 20. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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AZ'320

Alle RIP kinase Isoform-spezifische Produkte anzeigen