BA-53038B
Based on 1 Customer Validation
BA-53038B is a HBV core protein allosteric modulator (CpAM), binding to the HAP pocket and modulating HBV capsid assembly. BA-53038B has antiviral activity for hepatitis B virus (HBV) with an EC50 value of 3.32 μM. BA-53038B can be used for the research of chronic hepatitis B.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.73%
- CAS. Nr.: 2306195-65-1
- Formel: C14H16ClNO
- Molecular Weight:249.74
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
EC 50: 3.32 μM (HBV)[1]
BA-53038B has antiviral activity for HBV with an EC50 value of 3.32 μM[1].
BA-53038B has cytotoxicity with CC50 value of >100 μM[1].
BA-53038B (5 μM; 48 h) induces the capsid/nucleocapsid mobility shift and reduced the amount of hypophosphorylated core protein[1].
BA-53038B (0-20 μM; 2 or 6 days) inhibits HBV nucleocapsid assembly[1].
BA-53038B (5 μM; 2 days) inhibits pgRNA encapsidation and consequentially reduces the amount of DNA-containing capsids and hypophosphorylated core protein[1].
BA-53038B (2 μM; 6 h) modulates HBV capsid assembly by binding to the HAP pocket[1].
BA-53038B has resistant effect with an EC50 value of >10 μM on HBV capsid (HepG2 cells transiently transfected pHBV1.3/core-V124W)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:AML12HBV10 cells
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Concentration:5 μM
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Incubation Time:48 h
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Result:Reduced the amount of hypophosphorylated core protein and promoted the assembly of empty capsids with slow electrophoresis mobility.
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Cell Line:AML12HBV10 and HepDES19 cells
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Concentration:0-20 μM
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Incubation Time:2 or 6 days
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Result:Inhibited HBV replication in both AML12HBV10 and HepDES19 cells.
Chemical Information
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CAS. Nr. 2306195-65-1
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Appearance Solid
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Molecular Weight 249.74
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Formel C14H16ClNO
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Color White to off-white
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SMILES
O=C(NC1=CC=CC(Cl)=C1)C2C3CCCCC32
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 250 mg/mL (1001.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.0042 mL | 20.0208 mL | 40.0416 mL | 100.1041 mL |
| 5 mM | 0.8008 mL | 4.0042 mL | 8.0083 mL | 20.0208 mL | |
| 10 mM | 0.4004 mL | 2.0021 mL | 4.0042 mL | 10.0104 mL | |
| 15 mM | 0.2669 mL | 1.3347 mL | 2.6694 mL | 6.6736 mL | |
| 20 mM | 0.2002 mL | 1.0010 mL | 2.0021 mL | 5.0052 mL | |
| 25 mM | 0.1602 mL | 0.8008 mL | 1.6017 mL | 4.0042 mL | |
| 30 mM | 0.1335 mL | 0.6674 mL | 1.3347 mL | 3.3368 mL | |
| 40 mM | 0.1001 mL | 0.5005 mL | 1.0010 mL | 2.5026 mL | |
| 50 mM | 0.0801 mL | 0.4004 mL | 0.8008 mL | 2.0021 mL | |
| 60 mM | 0.0667 mL | 0.3337 mL | 0.6674 mL | 1.6684 mL | |
| 80 mM | 0.0501 mL | 0.2503 mL | 0.5005 mL | 1.2513 mL | |
| 100 mM | 0.0400 mL | 0.2002 mL | 0.4004 mL | 1.0010 mL |
BA-53038B Related Classifications
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