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Art. -Nr.: HY-149065

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D-685

D-685, a prodrug of D-520, exhibits higher in vivo anti-Parkinsonian efficacy in a reserpinized Parkinson's disease (PD) animal model than the parent D-520. D-685 reduces accumulation of human α-synuclein (α-syn) protein. D-685 exhibits facile brain penetration.

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CAS. Nr.: 2893801-00-6
Formel: C₃₂H₃₉N₃O₃
Molecular Weight:513.67

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

D-685 Chemical Structure

CAS. Nr.: 2893801-00-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
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Biologische Aktivität

Beschreibung

IC₅₀ & Target

α-synuclein Aggregation

Alle α-synuclein Isoform-spezifische Produkte anzeigen :

In Vivo

D-685 (12 mg/kg; intraperitoneally daily for 1 month) reduces the accumulation of α-synuclein in α-Syn tg mice^[1].
D-685 (10 μmol/kg; ip) is not only highly efficacious in reversing akinesia in male and female Sprague-Dawley rats weighing 220-225 g, compared to Reserpine (HY-N0480; 5.0 mg/kg; SC) alone, but also demonstrates significant enhancement of locomotion for the entire duration of the 6 h study^[1].
D-685 exhibits facile penetration into the brain under ip administration with a high brain-to-plasma ratio (B/P: 4)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Five-month-old D-Line α-syn tg Balb/c female mice 20-22 g^[1]
Dosage:

12 mg/kg
Administration:

Intraperitoneally daily for 1 month
Result:

Caused a significant reduction in α-syn accumulation in the neocortex and the striatum and a trend toward a reduction in the CA3 region of the hippocampus.
There was a significant reduction in phospho-α-syn accumulation in all regions examined.

Chemical Information

CAS. Nr. 2893801-00-6
Molecular Weight 513.67
Formel C₃₂H₃₉N₃O₃
SMILES

OC1=C2CC[C@H](N(CCN3CCN(C4=CC=C(C5=CC=C(OCO6)C6=C5)C=C4)CC3)CCC)CC2=CC=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Aloke K Dutta, et al. D-685 Reverses Motor Deficits and Reduces Accumulation of Human α-Synuclein Protein in Two Different Parkinson's Disease Animal Models. ACS Chem Neurosci. 2023 Mar 1;14(5):885-896. [Content Brief]

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Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
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- In Vivo
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D-685

Alle α-synuclein Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

D-685 Related Classifications

HY-149065 Related Classifications