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Art. -Nr.: HY-101779R

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DCG04 (Standard)

DCG04 (Standard) is the analytical standard of DCG04 (HY-101779). This product is intended for research and analytical applications. DCG04 is a biotinylated activity-based probe. DCG04 labels calpain-1 and is applicable for affinity purification and mass spectrometry identification. DCG04 is used in cancer and malaria research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 314263-42-8
Formel: C₄₃H₆₆N₈O₁₁S
Molecular Weight:903.10

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

DCG04 (Standard) Chemical Structure

CAS. Nr.: 314263-42-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

HY-101779
DCG04

Cysteine Protease Inhibitor

Product Information
- Information
- Anwendung
Chemical Information
Reinheit & Dokumentation
Calculators
Help & FAQs
Classifications
Bioz

Product Information

Information

Anwendung

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS. Nr. 314263-42-8
Molecular Weight 903.10
Formel C₄₃H₆₆N₈O₁₁S
SMILES

OC(C=C1)=CC=C1C[C@@H](C(NCCCCCC(N[C@H](C(N)=O)CCCCNC(CCCC[C@H]2[C@]3([H])[C@](NC(N3)=O)([H])CS2)=O)=O)=O)NC([C@H](CC(C)C)NC([C@@H]4[C@H](O4)C(OCC)=O)=O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Verweise

[1]. Joyce JA, et al. Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis. Cancer cell. 2004 May;5(5):443-53.

[2]. Greenbaum D, et al. Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools. Chemistry & biology. 2000 Aug;7(8):569-81.

[3]. Yasothornsrikul S, et al. Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter. Proceedings of the National Academy of Sciences of the United States of America. 2003 Aug 05;100(16):9590-5.

[4]. Hillaert U, et al. Receptor-mediated targeting of cathepsins in professional antigen presenting cells. Angewandte Chemie (International ed. in English). 2009;48(9):1629-32. [Content Brief]

[5]. Song J, et al. Apoplastic effectors secreted by two unrelated eukaryotic plant pathogens target the tomato defense protease Rcr3. Proceedings of the National Academy of Sciences of the United States of America. 2009 Feb 03;106(5):1654-9.

[6]. Lee J, et al. Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumain. ACS chemical biology. 2010 Feb 19;5(2):233-43.

[7]. Arastu-Kapur S, et al. Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum. Nature chemical biology. 2008 Mar;4(3):203-13.

[8]. Chandramohanadas R, et al. Apicomplexan parasites co-opt host calpains to facilitate their escape from infected cells. Science (New York, N.Y.). 2009 May 08;324(5928):794-7.

[9]. Deu E, et al. Ferrous iron-dependent drug delivery enables controlled and selective release of therapeutic agents in vivo. Proceedings of the National Academy of Sciences of the United States of America. 2013 Nov 05;110(45):18244-9.

[10]. Shree T, et al. Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer. Genes & development. 2011 Dec 01;25(23):2465-79.

[11]. Sueldo DJ, et al. Activity-based proteomics uncovers suppressed hydrolases and a neo-functionalised antibacterial enzyme at the plant-pathogen interface. The New phytologist. 2024 Jan;241(1):394-408.

[12]. Rooney HC, et al. Cladosporium Avr2 inhibits tomato Rcr3 protease required for Cf-2-dependent disease resistance. Science (New York, N.Y.). 2005 Jun 17;308(5729):1783-6.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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