Receptor-mediated targeting of cathepsins in professional antigen presenting cells

  • Angew Chem Int Ed Engl. 2009;48(9):1629-32. doi: 10.1002/anie.200805529.
Ulrik Hillaert  1 ,  Martijn Verdoes ,  Bogdan I Florea ,  Athanasios Saragliadis ,  Kim L L Habets ,  Johan Kuiper ,  Serge Van Calenbergh ,  Ferry Ossendorp ,  Gijsbert A van der Marel ,  Christoph Driessen ,  Hermen S Overkleeft
Affiliations
  • 1. Leiden Institute of Chemistry, Leiden University, P.O. Box 9052, 2300 RA Leiden, The Netherlands.
PMID: 19156780 DOI: 10.1002/anie.200805529
Abstract

Tag for professionals: A fluorescently tagged clustered mannoside DCG-04 analogue (see structure) is designed and synthesized using a modular approach. Uptake of the probe in professional antigen presenting cells and subsequent labeling of cathepsins proceeded in a mannose-receptor dependent manner.

Products