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Mapt - microtubule-associated protein tau Gene

Also Known as Tau; Mtapt; PHF-tau

Species: Mus musculus

Gene Type: protein coding

Gene ID: 17762

About Mapt

Chromosome 11: 104,122,216-104,222,916 forward strand.GRCm39:CM001004.3

This gene has 12 transcripts (splice variants), 225 orthologues, 1 paralogue and is associated with 70 phenotypes. Biased expression in CNS E18 (RPKM 123.), whole brain E14.5 (RPKM 8.2) and 9 other tissues.

Summary

Enables DNA binding activity; microtubule binding activity; and protein kinase binding activity. Involved in negative regulation of tubulin deacetylation; regulation of cellular response to heat; and regulation of response to DNA damage stimulus. Acts upstream of or within several processes, including adult walking behavior; generation of neurons; and transport along microtubule. Located in several cellular components, including cytoskeleton; glial cell projection; and postsynaptic density. Is expressed in several structures, including gut; nervous system; sensory organ; smooth muscle tissue; and urinary system. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); progressive supranuclear palsy; and temporal lobe epilepsy. Orthologous to human MAPT (microtubule associated protein tau). [provided by Alliance of Genome Resources, Apr 2022]

Mapt Products (32)

mRNA	Protein	Name
NM_001404014.1	NP_001390943.1	microtubule-associated protein tau isoform 5
NM_001403984.1	NP_001390913.1	microtubule-associated protein tau isoform 15
NM_001403994.1	NP_001390923.1	microtubule-associated protein tau isoform 19
NM_001403983.1	NP_001390912.1	microtubule-associated protein tau isoform 14
NM_001403996.1	NP_001390925.1	microtubule-associated protein tau isoform 20
NM_001403987.1	NP_001390916.1	microtubule-associated protein tau isoform 16
NM_001404011.1	NP_001390940.1	microtubule-associated protein tau isoform 2
NM_001403982.1	NP_001390911.1	microtubule-associated protein tau isoform 13
NM_001038609.3	NP_001033698.1	microtubule-associated protein tau isoform 1
NM_001403990.1	NP_001390919.1	microtubule-associated protein tau isoform 17
NM_001404006.1	NP_001390935.1	microtubule-associated protein tau isoform 26
NM_001403978.1	NP_001390907.1	microtubule-associated protein tau isoform 9
NM_001403975.1	NP_001390904.1	microtubule-associated protein tau isoform 6
NM_001404004.1	NP_001390933.1	microtubule-associated protein tau isoform 24
NM_001403980.1	NP_001390909.1	microtubule-associated protein tau isoform 11
NM_001404005.1	NP_001390934.1	microtubule-associated protein tau isoform 25
NM_001404016.1	NP_001390945.1	microtubule-associated protein tau isoform 5
NM_001404010.1	NP_001390939.1	microtubule-associated protein tau isoform 11
NM_001404012.1	NP_001390941.1	microtubule-associated protein tau isoform 5
NM_001285456.2	NP_001272385.1	microtubule-associated protein tau isoform 5
NM_001404015.1	NP_001390944.1	microtubule-associated protein tau isoform 5
NM_001403976.1	NP_001390905.1	microtubule-associated protein tau isoform 7
NM_001404002.1	NP_001390931.1	microtubule-associated protein tau isoform 23
NM_001285454.2	NP_001272383.1	microtubule-associated protein tau isoform 3
NM_001285455.2	NP_001272384.1	microtubule-associated protein tau isoform 4
NM_001403998.1	NP_001390927.1	microtubule-associated protein tau isoform 21
NM_001403992.1	NP_001390921.1	microtubule-associated protein tau isoform 18
NM_001403981.1	NP_001390910.1	microtubule-associated protein tau isoform 12
NM_001403977.1	NP_001390906.1	microtubule-associated protein tau isoform 8
NM_010838.5	NP_034968.3	microtubule-associated protein tau isoform 2
NM_001403999.1	NP_001390928.1	microtubule-associated protein tau isoform 22
NM_001403979.1	NP_001390908.1	microtubule-associated protein tau isoform 10

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables DNA binding	IDA IDA: Inferred from direct assay	21131359	MGI
enables enzyme binding	IPI IPI: Inferred from physical interaction	19457097	MGI
enables microtubule binding	IDA IDA: Inferred from direct assay	18202255	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18346207	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	11826099	MGI

Biological Process GO Annotation	Evidence	Verweise	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	21131359	MGI
acts upstream of or within adult walking behavior	IGI IGI: Inferred from genetic interaction	19074461	MGI
acts upstream of or within axo-dendritic transport	IGI IGI: Inferred from genetic interaction	20829454	MGI
acts upstream of or within axon extension	IMP IMP: Inferred from mutant phenotype	11891784	MGI
acts upstream of or within axonogenesis	IGI IGI: Inferred from genetic interaction	11891784	MGI
acts upstream of intracellular transport	IMP IMP: Inferred from mutant phenotype	16536727	MGI
acts upstream of or within microtubule cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	8202139	MGI
acts upstream of or within mitochondrion transport along microtubule	IMP IMP: Inferred from mutant phenotype	16536727	MGI
acts upstream of or within negative regulation of intracellular transport	IMP IMP: Inferred from mutant phenotype	16536727	MGI
involved in negative regulation of tubulin deacetylation	IGI IGI: Inferred from genetic interaction	19457097	MGI
acts upstream of or within neuron migration	IMP IMP: Inferred from mutant phenotype	19695252	MGI
involved in regulation of cellular response to heat	IMP IMP: Inferred from mutant phenotype	21131359	MGI
acts upstream of or within regulation of microtubule-based movement	IDA IDA: Inferred from direct assay	18202255	MGI

Cellular Component GO Annotation	Evidence	Verweise	Source
located in axon	IDA IDA: Inferred from direct assay	3147150	MGI
located in axoneme	IDA IDA: Inferred from direct assay	19004860	MGI
located in cell body	IDA IDA: Inferred from direct assay	11826099	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	20338169	MGI
located in cytosol	IDA IDA: Inferred from direct assay	21131359	MGI
located in glial cell projection	IDA IDA: Inferred from direct assay	11826099	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	11826099	MGI
located in microtubule cytoskeleton	IDA IDA: Inferred from direct assay	12074840	MGI
located in nucleus	IDA IDA: Inferred from direct assay	20338169	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	17114649	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mapt Protein Structure

PHA02682

Tubulin-binding

0
100
200
300
372 a.a.

Protein Preferred Names	Protein Names
microtubule-associated protein tau	neurofibrillary tangle protein paired helical filament-tau

Recombinant Mapt Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P71752	PNS-Tau/MAPT Protein, Mouse (P.pastoris, His)	P10637-1 (A2-L733)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P700422	PNS-Tau/MAPT Protein, Mouse (HEK293, His)	P10637-1 (A2-L733)	≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-132582	Diranersen	Inhibitor	93.23%	Phase 2

Inhibitory Antibodies (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-P991373	APNmAb005	Inhibitor	97.64%	Phase 1

Pre-clinical Phase

Bioactive Molecules (8)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-132582C	Diranersen sodium	Inhibitor	91.82%	Unkown
HY-P4808A	PHF6 TFA	Activator	99.45%	Unkown
HY-P4808	PHF6	Activator	99.17%	Unkown
HY-147149	BPN-15477	Modulator	99.92%	Unkown
HY-RS08140	MAPT Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08141	Mapt Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174215	TAU-IN-3	Inhibitor	/	Unkown
HY-RS08142	Mapt Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mapt	NCBI	NCBI:4137