Nbl1 - NBL1, DAN family BMP antagonist Gene

Also Known as DAN; NO3; Dana; D4H1S1733E

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17965

Summary

Enables BMP binding activity and morphogen activity. Involved in several processes, including determination of dorsal identity; negative regulation of monocyte chemotaxis; and sequestering of BMP in extracellular matrix. Acts upstream of or within negative regulation of BMP signaling pathway; neuron projection morphogenesis; and positive regulation of neuron differentiation. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain ventricular layer; embryo mesenchyme; limb; and nose. Orthologous to several human genes including MICOS10-NBL1 (MICOS10-NBL1 readthrough). [provided by Alliance of Genome Resources, Apr 2022]

Nbl1 Products (1)

mRNA Protein Name
NM_008675.2 NP_032701.2 neuroblastoma suppressor of tumorigenicity 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables BMP binding IDA
IDA: Inferred from direct assay
9660951 MGI
enables morphogen activity IDA
IDA: Inferred from direct assay
9660951 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15528323 MGI
Biological Process GO Annotation Evidence Verweise Source
involved in determination of dorsal identity IMP
IMP: Inferred from mutant phenotype
9660951 MGI
acts upstream of or within negative regulation of BMP signaling pathway IDA
IDA: Inferred from direct assay
23676271 MGI
involved in negative regulation of monocyte chemotaxis IDA
IDA: Inferred from direct assay
15528323 MGI
involved in nervous system development IMP
IMP: Inferred from mutant phenotype
9660951 MGI
acts upstream of neuron differentiation IDA
IDA: Inferred from direct assay
16325379 MGI
acts upstream of or within neuron projection morphogenesis IDA
IDA: Inferred from direct assay
16325379 MGI
acts upstream of or within positive regulation of neuron differentiation IDA
IDA: Inferred from direct assay
16325379 MGI
involved in sequestering of BMP in extracellular matrix IDA
IDA: Inferred from direct assay
9660951 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuroblastoma suppressor of tumorigenicity 1

  • N03

  • neuroblastoma, suppression of tumorigenicity 1

  • zinc finger protein DAN

Recombinant Nbl1 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P70076 NBL1 Protein, Mouse (HEK293, His) Q61477 (A17-D178) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS09056 NBL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18252 Nbl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24732 Nbl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nbl1 NCBI NCBI:4681