NBL1 - NBL1, DAN family BMP antagonist Gene

Homo sapiens

Also known as NB; DAN; NO3; DAND1; D1S1733E

Gene ID: 4681 | Gene type: protein coding

About NBL1

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:19,643,229-19,658,452 (from NCBI)

This gene has 14 transcripts (splice variants), 197 orthologues and 2 paralogues. Broad expression in ovary (RPKM 113.9), prostate (RPKM 98.5) and 20 other tissues.

Summary

This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 gene (GeneID 440574) have been observed. [provided by RefSeq, May 2013]

NBL1 Products(8)

mRNA	Protein	Name
NM_001204084.3	NP_001191013.1	neuroblastoma suppressor of tumorigenicity 1 isoform 2 precursor
NM_001204085.2	NP_001191014.1	neuroblastoma suppressor of tumorigenicity 1 isoform 2 precursor
NM_001204086.3	NP_001191015.1	neuroblastoma suppressor of tumorigenicity 1 isoform 3
NM_001278164.2	NP_001265093.1	neuroblastoma suppressor of tumorigenicity 1 isoform 2 precursor
NM_001278165.2	NP_001265094.1	neuroblastoma suppressor of tumorigenicity 1 isoform 2 precursor
NM_001278166.2	NP_001265095.1	neuroblastoma suppressor of tumorigenicity 1 isoform 2 precursor
NM_005380.8	NP_005371.2	neuroblastoma suppressor of tumorigenicity 1 isoform 2 precursor
NM_182744.4	NP_877421.2	neuroblastoma suppressor of tumorigenicity 1 isoform 1

NBL1 Protein Structure

DAN

0
100
181 a.a.

Protein Preferred Names

Protein Names

neuroblastoma suppressor of tumorigenicity 1

DAN domain family member 1

Recombinant NBL1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74736	NBL1 Protein, Human (HEK293, His)	P41271 (A17-D181)	≥95%
HY-P74737	NBL1 Protein, Human (HEK293, Fc)	P41271 (A17-D181)	≥95%

Related Diseases

Diseases

Alias

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Nodular Ganglioneuroblastoma

Ganglioneuroblastoma, Nodular

Neuroblastoma 1

Neuroblastoma, Susceptibility To, 1	NBLST1
Neuroblastoma, Susceptibility To, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09056	NBL1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NBL1	MGD	MGI:104591
Macaca mulatta	NBL1	VGNC	VGNC:108522
Bos taurus	NBL1	VGNC	VGNC:108521
Canis familiaris	NBL1	VGNC	VGNC:84431
Rattus norvegicus	NBL1	RGD	RGD:3151
Felis catus	NBL1	VGNC	VGNC:80289
Others	NBL1	NCBI