Sumo1 - small ubiquitin-like modifier 1 Gene

Also Known as GMP1; PIC1; SMT3; Ubl1; SMTP3; Smt3C; SMT3H3; SUMO-1; SENTRIN

Species: Mus musculus

Gene Type: protein coding

Gene ID: 22218

Summary

Predicted to enable enzyme binding activity; Potassium Channel regulator activity; and protein tag. Involved in several processes, including positive regulation of ATPase-coupled calcium transmembrane transporter activity; regulation of cardiac muscle cell contraction; and regulation of protein stability. Acts upstream of or within several processes, including PML body organization; protein localization to nuclear pore; and protein sumoylation. Located in XY body and nuclear body. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and heart. Human ortholog(s) of this gene implicated in orofacial cleft 10. Orthologous to human SUMO1 (small ubiquitin like modifier 1). [provided by Alliance of Genome Resources, Apr 2022]

Sumo1 Products (1)

mRNA	Protein	Name
NM_009460.2	NP_033486.1	small ubiquitin-related modifier 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15767674	MGI
enables transcription factor binding	IMP IMP: Inferred from mutant phenotype	15023536	MGI
enables transcription factor binding	IPI IPI: Inferred from physical interaction	15767674	MGI

Biological Process GO Annotation	Evidence	Verweise	Source
acts upstream of or within PML body organization	IMP IMP: Inferred from mutant phenotype	19033381	MGI
involved in positive regulation of ATPase-coupled calcium transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	21900893	MGI
acts upstream of or within protein localization to nuclear pore	IMP IMP: Inferred from mutant phenotype	19033381	MGI
acts upstream of or within protein sumoylation	IDA IDA: Inferred from direct assay	15767674	MGI
acts upstream of or within protein sumoylation	IMP IMP: Inferred from mutant phenotype	19033381	MGI
involved in protein sumoylation	IMP IMP: Inferred from mutant phenotype	15023536	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15767674	MGI
involved in regulation of calcium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	21900893	MGI
involved in regulation of cardiac muscle cell contraction	IMP IMP: Inferred from mutant phenotype	21900893	MGI
involved in regulation of protein stability	IMP IMP: Inferred from mutant phenotype	21900893	MGI
involved in roof of mouth development	IMP IMP: Inferred from mutant phenotype	16990542	MGI

Cellular Component GO Annotation	Evidence	Verweise	Source
located in XY body	IDA IDA: Inferred from direct assay	25634095	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	31749687	MGI
located in nuclear body	IDA IDA: Inferred from direct assay	18681895	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15767674	MGI
is active in postsynaptic cytosol	IDA IDA: Inferred from direct assay	31749687	MGI
is active in presynaptic cytosol	IDA IDA: Inferred from direct assay	31749687	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
small ubiquitin-related modifier 1	SMT3 homolog 3 SMT3 suppressor of mif two 3 homolog 1 SUMO-1 related peptidase ubiquitin-homology domain protein PIC1 ubiquitin-like 1 ubiquitin-like protein SMT3C

Sumo1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	Sumo1	P63166	Nr2c1	Mus musculus	Q505F1	Anti Bait CoIP	18682553
Cross	Sumo1	P63166	PAX6	Homo sapiens	P26367-1	Anti Bait CoIP	21084637
Intra	Sumo1	P63166	Ikzf1	Mus musculus	Q03267	Anti Bait CoIP	15767674

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-108702	ML-792	Inhibitor	99.76%	Unkown
HY-139662	HB007	Inhibitor	99.73%	Unkown
HY-RS14025	SUMO1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-181772	MCULE-3064932370	Inhibitor	/	Unkown
HY-RS17276	Sumo1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23730	Sumo1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sumo1	NCBI	NCBI:7341