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TRIM44 - tripartite motif containing 44 Gene

Also Known as AN3; MC7; DIPB; HSA249128

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54765

About TRIM44

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:35,662,775-35,818,007 (from NCBI)

This gene has 2 transcripts (splice variants), 175 orthologues, 80 paralogues and is associated with 3 phenotypes. Ubiquitous expression in brain (RPKM 26.6), thyroid (RPKM 23.0) and 25 other tissues.

Summary

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, namely a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008]

TRIM44 Products (1)

mRNA	Protein	Name
NM_017583.6	NP_060053.2	tripartite motif-containing protein 44

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17577209	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in negative regulation of protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	23460740	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	23460740	GOA
involved in positive regulation of cytokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	23460740	GOA
involved in positive regulation of defense response to virus by host	IDA IDA: Inferred from direct assay	23460740	GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	23460740	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	23460740	GOA
involved in regulation of gene expression	IMP IMP: Inferred from mutant phenotype	26394807	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM44 Protein Structure

zf-B_box

0
100
200
300
344 a.a.

Protein Preferred Names	Protein Names
tripartite motif-containing protein 44

TRIM44 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	TRIM44	Q96DX7	PBX3	Homo sapiens	Q5JS98	Validated Y2H	25416956
Intra	TRIM44	Q96DX7	TRIM10	Homo sapiens	Q9UDY6-2	Validated Y2H	32296183
Intra	TRIM44	Q96DX7	TRIM69	Homo sapiens	Q86WT6	Validated Y2H	25416956
Intra	TRIM44	Q96DX7	TRIM69	Homo sapiens	Q86WT6	Y2H Array	25416956
Intra	TRIM44	Q96DX7	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Aniridia 3	AN3 Aniridia, Type 3
Isolated Aniridia
Supraglottis Neoplasm	Neoplasm Of Supraglottis Supraglottic Tumor
Gillespie Syndrome	GLSP Aniridia, Cerebellar Ataxia And Mental Deficiency Aniridia Cerebellar Ataxia Mental Deficiency Aniridia, Cerebellar Ataxia, And Mental Retardation Aniridia-Cerebellar Ataxia-Intellectual Disability Syndrome Aniridia-Cerebellar Ataxia-Intellectual Disability Aniridia-Cerebellar Ataxia-Mental Deficiency Partial Aniridia-Cerebellar Ataxia-Oligophrenia Aniridia, Cerebellar Ataxia, And Intellectual Disability
Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome	Wagr Syndrome 11p Partial Monosomy Syndrome Chromosome 11p13 Deletion Syndrome Wilms Tumor, Aniridia, Genitourinary Anomalies And Mental Retardation Syndrome 11p Deletion Syndrome Chromosome 11p Deletion Syndrome Wagr Complex Wilms Tumor-Aniridia-Genitourinary Anomalies-Intellectual Disability Syndrome Deletion 11p13 WAGR Wilms Tumor-Aniridia-Genitourinary Anomalies-Mental Retardation Syndrome Chromosome 11p Deletion 11p Deletion 11p Monosomy Deletion 11p Monosomy 11p Partial Monosomy 11p Agr Triad Wilms Tumor-Aniridia-Gonadoblastoma-Mental Retardation Syndrome Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation Syndrome Wagr Contiguous Gene Syndrome Wilms Tumor-Aniridia-Genital Anomalies-Retardation Syndrome Wilms Tumor-Aniridia-Genitourinary Anomalies-Mr Syndrome Del(11)(P13) Monosomy 11p13 Chromosome 11, Deletion 11p
Aniridia 1	Aniridia Congenital Aniridia AN1 An Cataract With Late-Onset Corneal Dystrophy Aplasia Of Iris Absent Iris Irideremia Aniridia Ii, Formerly An2, Formerly An2 Aniridia Type Ii Aniridia, Type 1 An-1 Absence Of Iris Agenesis Of Iris Congenital Absence Of Iris Hereditary Aniridia Sporadic Aniridia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-183624	Trimer44NMe		/	Unkown
HY-RS15048	TRIM44 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21962	Trim44 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28479	Trim44 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TRIM44	VGNC	VGNC:36336
Canis familiaris	TRIM44	VGNC	VGNC:47823
Felis catus	TRIM44	VGNC	VGNC:66540
Rattus norvegicus	TRIM44	RGD	RGD:1304877
Mus musculus	TRIM44	MGD	MGI:1931835
Macaca mulatta	TRIM44	VGNC	VGNC:79168
Others	TRIM44	NCBI