TACC1 - transforming acidic coiled-coil containing protein 1 Gene

Also Known as Ga55

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6867

About TACC1

Cytogenetic location: 8p11.22 Genomic coordinates (GRCh38): 8:38,728,582-38,853,028 (from NCBI)

This gene has 29 transcripts (splice variants), 264 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in fat (RPKM 59.1), endometrium (RPKM 38.3) and 24 other tissues.

Summary

This locus may represent a breast Cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]

TACC1 Products (31)

mRNA Protein Name
NM_001122824.2 NP_001116296.1 transforming acidic coiled-coil-containing protein 1 isoform 2
NM_001146216.3 NP_001139688.1 transforming acidic coiled-coil-containing protein 1 isoform 3
NM_001330521.2 NP_001317450.1 transforming acidic coiled-coil-containing protein 1 isoform 4
NM_001352778.2 NP_001339707.1 transforming acidic coiled-coil-containing protein 1 isoform 5
NM_001352779.2 NP_001339708.1 transforming acidic coiled-coil-containing protein 1 isoform 6
NM_001352780.2 NP_001339709.1 transforming acidic coiled-coil-containing protein 1 isoform 7
NM_001352781.2 NP_001339710.1 transforming acidic coiled-coil-containing protein 1 isoform 8
NM_001352782.2 NP_001339711.1 transforming acidic coiled-coil-containing protein 1 isoform 9
NM_001352783.2 NP_001339712.1 transforming acidic coiled-coil-containing protein 1 isoform 10
NM_001352784.2 NP_001339713.1 transforming acidic coiled-coil-containing protein 1 isoform 11
NM_001352785.2 NP_001339714.1 transforming acidic coiled-coil-containing protein 1 isoform 12
NM_001352786.2 NP_001339715.1 transforming acidic coiled-coil-containing protein 1 isoform 13
NM_001352787.2 NP_001339716.1 transforming acidic coiled-coil-containing protein 1 isoform 14
NM_001352788.2 NP_001339717.1 transforming acidic coiled-coil-containing protein 1 isoform 15
NM_001352789.2 NP_001339718.1 transforming acidic coiled-coil-containing protein 1 isoform 3
NM_001352790.2 NP_001339719.1 transforming acidic coiled-coil-containing protein 1 isoform 3
NM_001352791.1 NP_001339720.1 transforming acidic coiled-coil-containing protein 1 isoform 3
NM_001352792.2 NP_001339721.1 transforming acidic coiled-coil-containing protein 1 isoform 16
NM_001352793.2 NP_001339722.1 transforming acidic coiled-coil-containing protein 1 isoform 17
NM_001352794.2 NP_001339723.1 transforming acidic coiled-coil-containing protein 1 isoform 17
NM_001352795.2 NP_001339724.1 transforming acidic coiled-coil-containing protein 1 isoform 4
NM_001352796.2 NP_001339725.1 transforming acidic coiled-coil-containing protein 1 isoform 4
NM_001352797.2 NP_001339726.1 transforming acidic coiled-coil-containing protein 1 isoform 4
NM_001352798.1 NP_001339727.1 transforming acidic coiled-coil-containing protein 1 isoform 4
NM_001352799.2 NP_001339728.1 transforming acidic coiled-coil-containing protein 1 isoform 18
NM_001352800.2 NP_001339729.1 transforming acidic coiled-coil-containing protein 1 isoform 19
NM_001352801.2 NP_001339730.1 transforming acidic coiled-coil-containing protein 1 isoform 20
NM_001352802.1 NP_001339731.1 transforming acidic coiled-coil-containing protein 1 isoform 21
NM_001352803.2 NP_001339732.1 transforming acidic coiled-coil-containing protein 1 isoform 22
NM_001352804.2 NP_001339733.1 transforming acidic coiled-coil-containing protein 1 isoform 23
NM_006283.3 NP_006274.2 transforming acidic coiled-coil-containing protein 1 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables nuclear estrogen receptor binding IDA
IDA: Inferred from direct assay
20078863 GOA
enables nuclear glucocorticoid receptor binding IDA
IDA: Inferred from direct assay
20078863 GOA
enables nuclear receptor binding IDA
IDA: Inferred from direct assay
20078863 GOA
enables nuclear receptor coactivator activity IMP
IMP: Inferred from mutant phenotype
20078863 GOA
enables nuclear retinoic acid receptor binding IDA
IDA: Inferred from direct assay
20078863 GOA
enables nuclear retinoid X receptor binding IDA
IDA: Inferred from direct assay
20078863 GOA
enables nuclear thyroid hormone receptor binding IDA
IDA: Inferred from direct assay
20078863 GOA
enables peroxisome proliferator activated receptor binding IDA
IDA: Inferred from direct assay
20078863 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11903063 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TACC1 Protein Structure

TACC

TACC: Transforming acidic coiled-coil-containing protein (TACC) (599 - 803)

  • 0
  • 200
  • 400
  • 600
  • 805 a.a.
Protein Preferred Names Protein Names

transforming acidic coiled-coil-containing protein 1

  • gastric cancer antigen Ga55

TACC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
TACC1 O75410 MEMO1 Homo sapiens Q9Y316
Y2H Prey Pooling
25416956
Intra
TACC1 O75410 MEMO1 Homo sapiens Q9Y316
Y2H Array
25416956
Intra
TACC1 O75410 THAP12 Homo sapiens O43422
Y2H Array
25416956
Intra
TACC1 O75410 BTRC Homo sapiens Q9Y297
Anti Tag CoIP
33961781
Intra
TACC1 O75410 BTRC Homo sapiens Q9Y297
Y2H Array
31515488
Intra
TACC1 O75410 CKAP5 Homo sapiens Q14008
Y2H
11903063
Intra
TACC1 O75410 CKAP5 Homo sapiens Q14008
Anti Tag CoIP
14603251
Intra
TACC1 O75410 YEATS4 Homo sapiens O95619
IF
11903063
Intra
TACC1 O75410 YEATS4 Homo sapiens O95619
Y2H
11903063
Intra
TACC1 O75410 TDRD7 Homo sapiens Q8NHU6
Anti Bait CoIP
14603251
Intra
TACC1 O75410 TDRD7 Homo sapiens Q8NHU6
Pull Down
14603251
Intra
TACC1 O75410 TDRD7 Homo sapiens Q8NHU6
Y2H
14603251
Intra
TACC1 O75410 STX5 Homo sapiens Q13190
Y2H Prey Pooling
25416956
Intra
TACC1 O75410 STX5 Homo sapiens Q13190
Validated Y2H
25416956
Intra
TACC1 O75410 SH2D4A Homo sapiens Q9H788
Y2H Array
25416956
Intra
TACC1 O75410 SH2D4A Homo sapiens Q9H788
Validated Y2H
25416956
Intra
TACC1 O75410 SH2D4A Homo sapiens Q9H788
Y2H Array
31515488
Intra
TACC1 O75410 SH2D4A Homo sapiens Q9H788
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Giant Cell Glioblastoma

  • Monstrocellular Sarcoma
Gliosarcoma

  • Glioblastoma With Sarcomatous Component

  • Sarcomatous Glioblastoma
Neurofibrosarcoma

  • Neurosarcoma

  • Malignant Peripheral Nerve Sheath Tumor
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Dysembryoplastic Neuroepithelial Tumor

  • Dysembryoplastic Neuroepithelial Tumour

  • Dysembryoplastic Neuroepithelial Neoplasm

  • Dnet
Cerebellar Astrocytoma

  • Astrocytoma Of Cerebellum
Pilocytic Astrocytoma Of Cerebellum

  • Cerebellar Pilocytic Astrocytoma
Pilomyxoid Astrocytoma
Pilocytic Astrocytoma

  • Juvenile Pilocytic Astrocytoma

  • Grade I Astrocytic Tumor

  • Piloid Astrocytoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS14139 TACC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TACC1 RGD RGD:1303120
Felis catus TACC1 VGNC VGNC:65918
Bos taurus TACC1 VGNC VGNC:35557
Canis familiaris TACC1 VGNC VGNC:47063
Mus musculus TACC1 MGD MGI:2443510
Macaca mulatta TACC1 VGNC VGNC:78080
Others TACC1 NCBI