TDRD7 - tudor domain containing 7 Gene

Also Known as TRAP; CATC4; PCTAIRE2BP

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 23424

About TDRD7

Cytogenetic location: 9q22.33 Genomic coordinates (GRCh38): 9:97,412,096-97,496,125 (from NCBI)

This gene has 2 transcripts (splice variants), 265 orthologues, 6 paralogues and is associated with 3 phenotypes. Broad expression in testis (RPKM 24.1), duodenum (RPKM 7.8) and 24 other tissues.

Summary

The protein encoded by this gene belongs to the Tudor family of proteins. This protein contains conserved Tudor domains and LOTUS domains. It is a component of RNA granules, which function in RNA processing. Mutations in this gene have been associated with cataract formation in mouse and human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

TDRD7 Products (2)

mRNA	Protein	Name
NM_001302884.2	NP_001289813.1	tudor domain-containing protein 7 isoform 2
NM_014290.3	NP_055105.2	tudor domain-containing protein 7 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables mRNA binding	IDA IDA: Inferred from direct assay	21436445	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14603251	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in lens fiber cell differentiation	IMP IMP: Inferred from mutant phenotype	21436445	GOA
involved in lens morphogenesis in camera-type eye	IMP IMP: Inferred from mutant phenotype	21436445	GOA
involved in post-transcriptional regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21436445	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in ribonucleoprotein granule	IDA IDA: Inferred from direct assay	21436445	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TDRD7 Protein Structure

OST-HTH

TUDOR

0
200
400
600
800
1000
1098 a.a.

Protein Preferred Names	Protein Names
tudor domain-containing protein 7	PCTAIRE2-binding protein

TDRD7 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	TDRD7	Q8NHU6	CDKN2A	Homo sapiens	P42771	Anti Tag CoIP	21988832
Intra	TDRD7	Q8NHU6	GABPB1	Homo sapiens	Q06547	Y2H Prey Pooling	25416956
Intra	TDRD7	Q8NHU6	TACC1	Homo sapiens	O75410-1	Anti Bait CoIP	14603251
Intra	TDRD7	Q8NHU6	TACC1	Homo sapiens	O75410-1	Anti Tag CoIP	14603251

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Cataract 36	CTRCT36 Catc4 Autosomal Recessive Congenital Cataract 4 Cataract, Autosomal Recessive Congenital 4 Cataract, Type 36
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
Deprivation Amblyopia	Disuse Amblyopia Stimulus Deprivation Amblyopia
Deafness, Autosomal Dominant 5	DFNA5 Autosomal Dominant Nonsyndromic Deafness 5 Autosomal Dominant Deafness 5 Deafness, Autosomal Dominant, 5 Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 5 Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 5 Deafness, Autosomal Dominant, Type 5
Ayme-Gripp Syndrome	AYGRP Cataracts, Congenital, With Sensorineural Deafness, Down Syndrome-Like Facial Appearance, Short Stature, And Mental Retardation Aymé-Gripp Syndrome Fine-Lubinsky Syndrome Brachycephaly-Deafness-Cataract-Intellectual Disability Syndrome Brachycephaly-Hearing Loss-Cataract-Intellectual Disability Syndrome
Differentiating Neuroblastoma
Juvenile Glaucoma	Glaucoma Of Childhood Hydrophthalmos
Amblyopia	Lazy Eye
Anterior Segment Dysgenesis	Anterior Segment Developmental Anomaly Anterior Segment Mesenchymal Dysgenesis Corneal Opacification And Other Ocular Anomalies Sclerocornea With Other Ocular Anomalies Asmd Asod Anterior Segment Ocular Dysgenesis Foxe3-Related Ocular Disorder Familial Ocular Anterior Segment Mesenchymal Dysgenesis Dysgenesis, Anterior Segment Irido-Corneal Dysgenesis Axenfeld-Rieger Syndrome, Type 3
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism
Nanophthalmos	Nanophthalmia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS14338	TDRD7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22851	Tdrd7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29365	Tdrd7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Macaca mulatta	TDRD7	VGNC	VGNC:79886
Rattus norvegicus	TDRD7	RGD	RGD:619724
Bos taurus	TDRD7	VGNC	VGNC:35721
Mus musculus	TDRD7	MGD	MGI:2140279
Felis catus	TDRD7	VGNC	VGNC:66050
Canis familiaris	TDRD7	VGNC	VGNC:47225
Others	TDRD7	NCBI