KCTD10 - potassium channel tetramerization domain containing 10 Gene

Also Known as BTBD28; ULRO61; MSTP028; hBACURD3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 83892

About KCTD10

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:109,448,655-109,477,300 (from NCBI)

This gene has 16 transcripts (splice variants), 251 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 26.1), endometrium (RPKM 18.7) and 24 other tissues.

Summary

The protein encoded by this gene binds proliferating cell nuclear antigen (PCNA) and may be involved in DNA synthesis and cell proliferation. In addition, the encoded protein may be a tumor suppressor. Several protein-coding and non-protein coding transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]

KCTD10 Products (3)

mRNA Protein Name
NM_001317395.2 NP_001304324.1 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 isoform 1
NM_001317399.2 NP_001304328.1 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 isoform 3
NM_031954.5 NP_114160.1 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables Notch binding IPI
IPI: Inferred from physical interaction
25401743 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19615732 GOA
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
25401743 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCTD10 Protein Structure

BTB_2

BTB_2: BTB/POZ domain (34 - 124)

  • 0
  • 100
  • 200
  • 313 a.a.
Protein Preferred Names Protein Names

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

  • BTB/POZ domain-containing protein KCTD10

KCTD10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
KCTD10 Q9H3F6 TEX11 Homo sapiens Q8IYF3-3
Y2H Prey Pooling
32296183
Intra
KCTD10 Q9H3F6 TEX11 Homo sapiens Q8IYF3-3
Y2H Array
32296183
Intra
KCTD10 Q9H3F6 TNFAIP1 Homo sapiens Q13829
Y2H Prey Pooling
32296183
Intra
KCTD10 Q9H3F6 TNFAIP1 Homo sapiens Q13829
Y2H Array
32296183
Intra
KCTD10 Q9H3F6 KCTD13 Homo sapiens Q8WZ19
Y2H Prey Pooling
32296183
Intra
KCTD10 Q9H3F6 KCTD13 Homo sapiens Q8WZ19
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Methylmalonic Aciduria, Cblb Type

  • Methylmalonic Aciduria Cblb Type

  • Methylmalonic Acidemia Cblb Type

  • Methylmalonic Aciduria, Vitamin B12-Responsive, Due To Defect In Synthesis Of Adenosylcobalamin, Cblb Complementation Type

  • Methylmalonic Acidemia, Cblb Type

  • Methylmalonic Aciduria, Vitamin B12-Responsive, Due To Defect In Synthesis Of Adenosylcobalamin, Cblb Type

  • Methylmalonic Aciduria, Vitamin B12-Responsive, Cblb Type

  • Vitamin B12-Responsive Methylmalonic Acidemia Type Cblb

  • Vitamin B12-Responsive Methylmalonic Aciduria, Type Cblb

  • Methylmalonic Aciduria Type Cblb

  • MMAB

  • Methylmalonic Aciduria Type B

  • Vitamin B12 Responsive Methylmalonic Acidemia Type Cbl B

  • Vitamin B12 Responsive Methylmalonic Aciduria Type Cbl B

  • Aciduria, Methylmalonic, Cblb Type

  • Methylmalonic Acidemia

  • Methylmalonic Aciduria
Scalp-Ear-Nipple Syndrome

  • Finlay-Marks Syndrome

  • Sen Syndrome

  • SENS

  • Scalp Ear Nipple Syndrome

  • Hereditary Syndrome Of Lumpy Scalp, Odd Ears And Rudimentary Nipples

  • Hereditary Syndrome Of Lumpy Scalp, Odd Ears, And Rudimentary Nipples

  • Indian Childhood Cirrhosis
Branchiooculofacial Syndrome

  • Branchio-Oculo-Facial Syndrome

  • BOFS

  • Bof Syndrome

  • Hemangiomatous Branchial Clefts-Lip Pseudocleft Syndrome

  • Lip Pseudocleft-Hemangiomatous Branchial Cyst Syndrome

  • Branchial Clefts With Characteristic Facies, Growth Retardation, Imperforate Nasolacrimal Duct, And Premature Aging

  • Branchial Clefts With Characteristic Facies Growth Retardation Imperforate Nasolacrimal Duct And Premature Aging

  • Bofs Syndrome

  • Lip Pseudocleft-Hemagiomatous Branchial Cyst Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS07187 KCTD10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta KCTD10 VGNC VGNC:73893
Felis catus KCTD10 VGNC VGNC:63053
Canis familiaris KCTD10 VGNC VGNC:42300
Mus musculus KCTD10 MGD MGI:2141207
Rattus norvegicus KCTD10 RGD RGD:1591979
Bos taurus KCTD10 VGNC VGNC:30500
Others KCTD10 NCBI