MAGI1 - membrane associated guanylate kinase, WW and PDZ domain containing 1 Gene

Also Known as AIP3; BAP1; WWP3; AIP-3; BAP-1; BAIAP1; MAGI-1; Magi1d; TNRC19; MAGI-1b

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9223

About MAGI1

Cytogenetic location: 3p14.1 Genomic coordinates (GRCh38): 3:65,353,526-66,038,918 (from NCBI)

This gene has 18 transcripts (splice variants), 1 gene allele, 288 orthologues and 6 paralogues. Ubiquitous expression in thyroid (RPKM 5.4), brain (RPKM 4.9) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

MAGI1 Products (6)

mRNA Protein Name
NM_001033057.2 NP_001028229.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform c
NM_001365903.2 NP_001352832.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform d
NM_001365904.2 NP_001352833.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform e
NM_001365905.1 NP_001352834.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform f
NM_004742.3 NP_004733.2 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform b
NM_015520.2 NP_056335.1 membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables alpha-actinin binding IPI
IPI: Inferred from physical interaction
16464232 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9647693 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in positive regulation of cell-cell adhesion IDA
IDA: Inferred from direct assay
20298433 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in cell periphery IDA
IDA: Inferred from direct assay
20298433 GOA
located in cell projection IDA
IDA: Inferred from direct assay
16464232 GOA
located in cell-cell junction IDA
IDA: Inferred from direct assay
20298433 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
16464232 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
20298433 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAGI1 Protein Structure

Guanylate_kin

Guanylate_kin: Guanylate kinase (139 - 191)

WW

WW: WW domain (302 - 331)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (476 - 542)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (644 - 720)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (819 - 893)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (971 - 1061)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (1124 - 1199)

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  • 1200
  • 1462 a.a.
Protein Preferred Names Protein Names

membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

  • BAI1-associated protein 1

MAGI1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Cross
MAGI1 Q96QZ7 E6 Human papillomavirus P03126
SLC
22898364
Cross
MAGI1 Q96QZ7 E6 Human papillomavirus P03126
Pull Down
12444549
Cross
MAGI1 Q96QZ7 E6 Human papillomavirus P06463
SLC
22898364
Cross
MAGI1 Q96QZ7 E6 Human papillomavirus P06463
Pull Down
17267502
Intra
MAGI1 Q96QZ7 FCHSD2 Homo sapiens O94868
Pull Down
14627983
Intra
MAGI1 Q96QZ7 FCHSD2 Homo sapiens O94868
Y2H
14627983
Intra
MAGI1 Q96QZ7 IQGAP1 Homo sapiens P46940
Confocal
22662192
Intra
MAGI1 Q96QZ7 IQGAP1 Homo sapiens P46940
PLA
22662192
Intra
MAGI1 Q96QZ7 KIF1B Homo sapiens O60333-3
Y2H
12097473
Intra
MAGI1 Q96QZ7 KIF1B Homo sapiens O60333-3
Pull Down
12097473
Cross
MAGI1 Q96QZ7 M Rabies virus P0DOF2
Phage Display
37100772
Cross: Cross-species interaction Intra: Intraspecies interaction

MAGI1 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P86953 MAGI1 Antibody (YA6646) WB Human, Mouse, Rat

Related Diseases

Diseases Alias
Cervical Large Cell Neuroendocrine Carcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS02890 CNKSR3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07981 MAGI1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18856 Cnksr3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20444 Magi1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25348 Cnksr3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26953 Magi1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MAGI1 RGD RGD:1586025
Macaca mulatta MAGI1 VGNC VGNC:74499
Bos taurus MAGI1 VGNC VGNC:31147
Mus musculus MAGI1 MGD MGI:1203522
Felis catus MAGI1 VGNC VGNC:69081
Canis familiaris MAGI1 VGNC VGNC:108248
Others MAGI1 NCBI