2. Gene
  3. FCHSD2 - FCH and double SH3 domains 2 Gene

FCHSD2 - FCH and double SH3 domains 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NWK; NWK1; SH3MD3

Gene ID: 9873 | Gene type: protein coding

About FCHSD2

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:72,836,745-73,142,318 (from NCBI)

This gene has 9 transcripts (splice variants), 287 orthologues and 1 paralogue. Ubiquitous expression in spleen (RPKM 18.6), lymph node (RPKM 17.3) and 25 other tissues.

Summary

Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in clathrin-dependent endocytosis and positive regulation of Arp2/3 complex-mediated actin nucleation. Located in plasma membrane. Colocalizes with clathrin-coated pit. [provided by Alliance of Genome Resources, Apr 2022]

FCHSD2 Products(1)

mRNA Protein Name
NM_014824.3 NP_055639.2 F-BAR and double SH3 domains protein 2

FCHSD2 Protein Structure

FCH

FCH: Fes/CIP4, and EFC/F-BAR homology domain (16 - 108)

SH3_1

SH3_1: SH3 domain (476 - 521)

SH3_9

SH3_9: Variant SH3 domain (574 - 625)

  • 0
  • 200
  • 400
  • 600
  • 740 a.a.
Protein Preferred Names Protein Names

F-BAR and double SH3 domains protein 2

FCH and double SH3 domains protein 2

Related Diseases

Diseases Alias
Alzheimer Disease 14

AD14

Alzheimer'S Disease 14

Alzheimer Disease-14

Alzheimer'S Disease 14, Late Onset
Erythematosquamous Dermatosis

Other Erythematosquamous Dermatosis
Inflammatory Bowel Disease 9

IBD9
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04837 FCHSD2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus FCHSD2 MGD MGI:2448475
Canis familiaris FCHSD2 VGNC VGNC:40807
Macaca mulatta FCHSD2 VGNC VGNC:72593
Felis catus FCHSD2 VGNC VGNC:62213
Rattus norvegicus FCHSD2 RGD RGD:1304812
Bos taurus FCHSD2 VGNC VGNC:28937