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Art. -Nr.: HY-170851

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GL392

GL392 is a senolytic agent that selectively delivers the potent senolytic compound Dasatinib (HY-10181) to senescent cells. GL392 targets lipofuscin in senescent cells via the LBD domain and is linked to Dasatinib through an ester bond. Upon internalization in senescent cells, Dasatinib is released, inducing apoptosis of the senescent cells. GL392 in micelle encapsulation (mGL392) enables selective delivery to senescent cells, achieving selective senescent cell elimination in vitro and in vivo. GL392 can be used for the research of melanoma.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₅₅H₅₂ClN₁₃O₅S
Molecular Weight:1042.60

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

GL392 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

mGL392 (20-160 nM, 4 days) does not affect non-senescent B16 melanoma growth^[1].
mGL392 (10 nM) selectively accumulates within senescent cells in HBEC CDC6 Tet-ON and Li-Fraumeni-p21^WAF1/Cip1 Tet-ON cells^[1].
mGL392 (500 nM, 4 days) induces targeted senolysis in 3D patient-derived lung organoids^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

B16 cells
Concentration:

20, 80, 160 nM
Incubation Time:

4 days
Result:

Showed no affect on non-senescent B16 melanoma growth.

In Vivo

GL392 (0.015 mg; i.p.; daily; 9 days) induces selective senolysis in Palbociclib (HY-50767)-induced senescent melanoma cells in mice, reducing tumor volume by targeting senescent cells without systemic toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 (8-10 weeks old) subcutaneously injected with B16 melanoma cells, followed by Palbociclib-induced senescence^[1]
Dosage:

0.015 mg per mouse
Administration:

i.p.; daily; 9 days
Result:

Reduced tumor volume significantly.
Induced tumor cell apoptosis.
Did not affect non-senescent B16 melanoma cell viability in vivo when senescence was absent.
Left serum markers of liver, kidney, and muscle function (including ALP, AST/ALT ratio, and CPK) within normal ranges, with no histopathological damage to vital organs observed.

Chemical Information

Molecular Weight 1042.60
Formel C₅₅H₅₂ClN₁₃O₅S
SMILES

CC1(COC(CCC(OCCN2CCN(C3=CC(NC4=NC=C(C(NC5=C(C)C=CC=C5Cl)=O)S4)=NC(C)=N3)CC2)=O)=O)NC6=CC=CC(C6=C(N1)C=C7)=C7/N=N/C(C=C8)=C9C(C=CC=C9)=C8/N=N/C%10=CC=CC=C%10
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Magkouta S, et al. Generation of a selective senolytic platform using a micelle-encapsulated Sudan Black B conjugated analog. Nat Aging. 2025;5(1):162-175. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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