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Itanistomig

(Synonyms: LB-101)
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Itanistomig (LB-101) is a tetravalent bispecific antibody targeting PD-L1 and CD47. Itanistomig blocks PD-L1 and achieves tumor enrichment through binding to PD-L1, and also exerts conditional CD47 blocking activity via cleavage of the hinge linker in the PD-L1-positive tumor microenvironment. Itanistomig induces antibody-dependent cellular phagocytosis in human CD14+ cells and drives tumor regression. Itanistomig can be used in research related to solid tumors.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

  • Reinheit: 95.84%
  • CAS. Nr.: 2923687-56-1
  • Molecular Weight:243.635 kDa
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Itanistomig
  • Experimental Validation Results for Itanistomig
  • Experimental Validation Results for Itanistomig
  • Experimental Validation Results for Itanistomig
  • Itanistomig Chemical Structure
    Itanistomig Chemical Structure
CAS. Nr.: 2923687-56-1
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Itanistomig Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Finden Sie Ihren Händler vor Ort Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    G1-Fab-kappa-IgG1-kappa

  • 1/16

    Immobilized PD-L1 Protein, Human (HEK293, HY-P72917) can bind Itanistomig. The EC50 for this effect is 129.7 ng/mL.

  • 1/16

    Immobilized FCGRT Protein, Human (GST, HY-P73361) can bind Itanistomig. The EC50 for this effect is 57.01 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 Jurkat cells labeling CD274 with Itanistomig (HY-P991004, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF488-conjugated Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Itanistomig Chemical Structure
    1/16
  • Itanistomig
  • Immobilized PD-L1 Protein, Human (HEK293, HY-P72917) can bind Itanistomig. The EC50 for this effect is 129.7 ng/mL.
  • Immobilized FCGRT Protein, Human (GST, HY-P73361) can bind Itanistomig. The EC50 for this effect is 57.01 ng/mL.
  • Flow cytometric analysis of 1X106 Jurkat cells labeling CD274 with Itanistomig (HY-P991004, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF488-conjugated Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • G1-Fab-kappa-IgG1-kappa