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Art. -Nr.: HY-18331

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MI-219

MI-219 is an antagonist for MDM2 with a K_i of 13.3 μM. MI-219 inhibits the MDM2-p53 interaction, inhibits thus the proliferation of FSCCL cells, with an IC₅₀ of 2.5 μM.

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CAS. Nr.: 908027-55-4
Formel: C₂₇H₃₂Cl₂FN₃O₄
Molecular Weight:552.47

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

MI-219 Chemical Structure

CAS. Nr.: 908027-55-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

MI-219 is an antagonist for MDM2 with a K_i of 13.3 μM. MI-219 inhibits the MDM2-p53 interaction, inhibits thus the proliferation of FSCCL cells, with an IC₅₀ of 2.5 μM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	1.1 μM Compound: 7, MI-219	Growth inhibition of human HCT116 cells expressing wild type p53 gene after 4 days by WST8 dye reduction assay Growth inhibition of human HCT116 cells expressing wild type p53 gene after 4 days by WST8 dye reduction assay	[PMID: 19928922]
HCT-116	IC₅₀	24.8 μM Compound: 7, MI-219	Growth inhibition of human HCT116 cells deficient in p53 gene expression after 4 days by WST8 dye reduction assay Growth inhibition of human HCT116 cells deficient in p53 gene expression after 4 days by WST8 dye reduction assay	[PMID: 19928922]
RS4-11	IC₅₀	0.54 μM Compound: 1, MI-219	Cytotoxicity against human RS4:11 cells expressing wild type p53 assessed as growth inhibition by WST-8 assay Cytotoxicity against human RS4:11 cells expressing wild type p53 assessed as growth inhibition by WST-8 assay	[PMID: 23786219]
SAOS-2	IC₅₀	15.4 μM Compound: 7, MI-219	Growth inhibition of human Saos2 cells deficient in p53 gene expression after 4 days by WST8 dye reduction assay Growth inhibition of human Saos2 cells deficient in p53 gene expression after 4 days by WST8 dye reduction assay	[PMID: 19928922]
SJSA-1	IC₅₀	0.7 μM Compound: 7, MI-219	Growth inhibition of human SJSA1 cells expressing wild type p53 gene after 4 days by WST8 dye reduction assay Growth inhibition of human SJSA1 cells expressing wild type p53 gene after 4 days by WST8 dye reduction assay	[PMID: 19928922]
SJSA-1	IC₅₀	0.89 μM Compound: 1, MI-219	Cytotoxicity against human SJSA1 cells expressing wild type p53 assessed as growth inhibition by WST-8 assay Cytotoxicity against human SJSA1 cells expressing wild type p53 assessed as growth inhibition by WST-8 assay	[PMID: 23786219]

Chemical Information

CAS. Nr. 908027-55-4
Molecular Weight 552.47
Formel C₂₇H₃₂Cl₂FN₃O₄
SMILES

O=C([C@H](N[C@@H]1CC(C)(C)C)[C@H](C2=CC=CC(Cl)=C2)[C@]31C(NC4=C3C=C(F)C(Cl)=C4)=O)NCC[C@H](O)CO
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Mohammad RM, et al., An MDM2 antagonist (MI-319) restores p53 functions and increases the life span of orally treated follicular lymphoma bearing animals. Mol Cancer. 2009 Dec 3;8:115. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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