MRK-A
MRK-A is a selective, blood-brain-barrier permeable mutant IDH1 inhibitor with an IC50 value of 5 nM. MRK-A inhibits 2-HG production. MRK-A has anti-cancer activity against brain tumors.
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- CAS. Nr.: 1934301-68-4
- Formel: C28H30N4O2
- Molecular Weight:454.56
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
IC50: 5 nM (mutant IDH1)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MOG-G-UVW | IC50 |
43 nM
Compound: MRK-A
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Antiproliferative activity against human MOG-G-UVW cells assessed as inhibition of cell proliferation incubated for 72 hrs by cell titer-Glo assay
Antiproliferative activity against human MOG-G-UVW cells assessed as inhibition of cell proliferation incubated for 72 hrs by cell titer-Glo assay
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[PMID: 35450359] |
Chemical Information
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CAS. Nr. 1934301-68-4
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Molecular Weight 454.56
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Formel C28H30N4O2
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SMILES
O=C(N1CC2=CC=CN=C2NC3=CC=C(N4CCOCC4)C=C13)C5CCC6=CC=CC=C6CC5
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
MRK-A Related Classifications
HY-124698 Related Classifications
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