N-0159
N-0159 is a type II transmembrane serine protease (TTSP) inhibitor with anti-influenza virus activity. N-0159 exhibits a Ki of 0.06 nM against matriptase and acts through competitive and reversible inhibition of matriptase catalytic activity. N-0159 inhibits H1N1 influenza virus replication in human bronchial epithelial cells (IC50 = 292 nM). N-0159 can be used for research related to influenza virus infection.
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- CAS. Nr.: 3068741-64-7
- Formel: C34H48N12O5S
- Molecular Weight:736.89
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Calu-3 | IC50 |
292 nM
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Inhibition of H1N1 virus replication in human bronchial epithelial Calu-3 cells infected with A/Puerto Rico/8/34 (PR8) at an MOI of 0.003, with viral titers evaluated 48 hrs post-infection.
Inhibition of H1N1 virus replication in human bronchial epithelial Calu-3 cells infected with A/Puerto Rico/8/34 (PR8) at an MOI of 0.003, with viral titers evaluated 48 hrs post-infection.
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37864572 |
In Vitro
N‑0159 features homophenylalanine at the P2 position, which increases side‑chain flexibility and promotes additional π‑aromatic interactions within the matriptase active site, accounting for its higher affinity relative to IN‑2[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 3068741-64-7
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Molecular Weight 736.89
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Formel C34H48N12O5S
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SMILES
N=C(N)NCCC[C@H](N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC1=CC=CC=C1)C(N[C@@H](CCCNC(N)=N)C(C2=NC3=CC=CC=C3S2)=O)=O)=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
N-0159 Related Classifications
HY-189098 Related Classifications
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