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Art. -Nr.: HY-111026

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PPQ-581

PPQ-581 is an anti-influenza agent with an EC₅₀ of 1 μM for preventing virus-induced cytopathic effects. PPQ-581 inhibits viral protein synthesis. PPQ-581 blocks the RNP nuclear export and cytoplasmic RNP aggregation.

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CAS. Nr.: 950381-32-5
Formel: C₂₅H₂₄FN₃O₃
Molecular Weight:433.47

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

PPQ-581 Chemical Structure

CAS. Nr.: 950381-32-5

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
MDCK	EC₅₀	1 μM Compound: 6a	Antiviral activity against Influenza A virus (A/WSN/1933(H1N1)) assessed as virus-mediated cytopathic effect in MDCK cells after 48 to 72 hrs Antiviral activity against Influenza A virus (A/WSN/1933(H1N1)) assessed as virus-mediated cytopathic effect in MDCK cells after 48 to 72 hrs	[PMID: 26310893]
MDCK	EC₅₀	1 μM Compound: 6a	Antiviral activity against Influenza A virus (A/WSN/1933(H1N1)) expressing nucleoprotein Y52H mutant assessed as virus-mediated cytopathic effect in MDCK cells Antiviral activity against Influenza A virus (A/WSN/1933(H1N1)) expressing nucleoprotein Y52H mutant assessed as virus-mediated cytopathic effect in MDCK cells	[PMID: 26310893]
MDCK	EC₅₀	1.4 μM Compound: 6a	Antiviral activity against Influenza A virus (A/WSN/1933(H1N1)) expressing nucleoprotein Y289H mutant assessed as virus-mediated cytopathic effect in MDCK cells Antiviral activity against Influenza A virus (A/WSN/1933(H1N1)) expressing nucleoprotein Y289H mutant assessed as virus-mediated cytopathic effect in MDCK cells	[PMID: 26310893]
MDCK	EC₅₀	2.3 μM Compound: 6a	Antiviral activity against wild-type Influenza A virus (A/WSN/1933(H1N1)) assessed as virus-mediated cytopathic effect in MDCK cells Antiviral activity against wild-type Influenza A virus (A/WSN/1933(H1N1)) assessed as virus-mediated cytopathic effect in MDCK cells	[PMID: 26310893]
MDCK	EC₅₀	8 μM Compound: 6a	Antiviral activity against Influenza A virus (A/WSN/1933(H1N1)) expressing nucleoprotein S377G mutant assessed as virus-mediated cytopathic effect in MDCK cells Antiviral activity against Influenza A virus (A/WSN/1933(H1N1)) expressing nucleoprotein S377G mutant assessed as virus-mediated cytopathic effect in MDCK cells	[PMID: 26310893]

Chemical Information

CAS. Nr. 950381-32-5
Molecular Weight 433.47
Formel C₂₅H₂₄FN₃O₃
SMILES

O=C1C2=C(N3C(C(C4=C(F)C=CC=C4)OCC3(C)C)=C2N(C)C(N1C)=O)C5=CC=CC=C5
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Lin MI, et al. Synthesis and inhibitory effects of novel pyrimido-pyrrolo-quinoxalinedione analogues targeting nucleoproteins of influenza A virus H1N1. Eur J Med Chem. 2015 Sep 18;102:477-86. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

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100 mg

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