CD43
CD43, also called leukosialin or sialophorin, is the most abundant sialoglycoprotein on the surface of most leukocytes, extended about 45 nanometers from the membrane by its heavily O-glycosylated, negatively charged extracellular mucin domain. This structure creates steric anti-adhesive effects, yet CD43 also promotes T-cell activation and migration by engaging ICAM-1, galectin-1 and ERM-linked cytoskeletal elements through its cytoplasmic tail. The molecule is expressed on T cells, NK cells, monocytes, granulocytes and platelets, while mature B cells are characteristically negative. Aberrant CD43 expression in B-cell lymphomas aids diagnosis, and Wiskott-Aldrich syndrome disrupts its surface expression.
-
CD43 Recombinant Proteins (5)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
