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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
389 Results for "
O2
" in MedChemExpress (MCE) Product Catalog:
Products (389)
389 Results for "O2" in MCE Product Catalog:
61
61 Publications Verification
Synonyms: PF-1005023
Target:
Forschungsgebiete:
UK-5099 (PF-1005023) is a potent inhibitor of the mitochondrial pyruvate carrier (MPC). UK-5099 (PF-1005023) inhibits pyruvate-dependent O2 consumption with an IC50 of 50 nM.
20
Category:
Human Gut Microbiota Metabolites Natural Products Microorganisms Anti-aging Metabolic Disease Endogenous metabolite Disease Research Fields
Target:
20
Category:
Natural Products other families Animals Metabolic Disease Plants Endogenous metabolite Disease Research Fields
Target:
19
Category:
Natural Products Neurological Disease Gastrodia elata Bl. Anti-aging Orchidaceae Phenols Plants Disease Research Fields Inflammation/Immunology
Target:
15
15 Cited Publications
Synonyms: Luteolin 7-glucoside; Luteolin 7-O-β-D-glucoside
12
12 Cited Publications
Target:
Forschungsgebiete:
CORM-401 is an oxidant-sensitive CO-releasing molecule. CORM-401 induces NO increase in the regulation of endothelial calcium signalling. CORM-401 reduces TNF-α/CHX and H2O2-induced ROS production. CORM-401 uncouples mitochondrial respiration and inhibits glycolysis [2] .
9
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Forschungsgebiete:
2,7-Dichlorodihydrofluorescein (DCFH2) is a non-fluorescent reactive oxygen species (ROS) probe with an excitation wavelength of 485-500 nm and an emission wavelength of 515-530 nm. 2,7-Dichlorodihydrofluorescein is first hydrolyzed by intracellular esterases and then oxidized by ROS to generate non-biomembrane-permeable, highly fluorescent 2,7-dichlorofluorescein (DCF). The fluorescence intensity of DCF is positively correlated with the ROS concentration. 2,7-Dichlorodihydrofluorescein can undergo oxidation reactions with a variety of ROS (such as ·OH, H2O2, ONOO -, etc.) and is used to quantitatively detect the level of oxidative stress inside and outside cells. It is suitable for oxidative stress analysis in in vitro cell models and in vivo targeted delivery (such as liver-targeted liposomes) [2].
8
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Forschungsgebiete:
Glucose oxidase is used in the food and beverage industry as a preservative and stabilizer and is commonly derived from the fungus Aspergillus niger. Glucose oxidase can react with intracellular glucose and oxygen (O2) to produce hydrogen peroxide (H2O2) and gluconic acid, which can cut off the nutrition source of cancer cells and consequently inhibit their proliferation [2] .
8
Evofosfamide (TH-302) is a hypoxia-activated proagent with IC50 of 10 μM and 1000 μM in hypoxia (N2) and normoxia (21% O2), respectively.
8
6
Category:
other families Flavonoids Monophenols Neurological Disease Flavones Phenols Plants Disease Research Fields Inflammation/Immunology
Target:
6
6 Cited Publications
Synonyms: Diethylnorspermine tetrahydrochloride; DENSPM tetrahydrochloride; BENSPM tetrahydrochloride
N1, N11-Diethylnorspermine tetrahydrochloride (DENSPM tetrahydrochloride) is a potent anticancer agent. N1,N11-Diethylnorspermine tetrahydrochloride activates polyamine catabolism and downregulates mTOR protein. N1,N11-Diethylnorspermine tetrahydrochloride induces the release of cytochrome c from mitochondria, resulting in activation of caspase 3. N1,N11-Diethylnorspermine tetrahydrochloride kills glioblastoma multiforme (GBM) through induction of SSAT (spermidine/spermine N1-acetyltransferase) coupled with H2O2 production [2] .
5
5 Cited Publications
Synonyms: Nuc-H2O2 Probe
5
Target:
Forschungsgebiete:
Catalase, Aspergillus niger is a key enzyme in the metabolism of H2O2 and reactive oxygen species (ROS), and its expression and localization is markedly altered in tumors . Free oxygen radical scavenger.
5
5 Cited Publications
Art. -Nr.: HY-D1157
CAS. Nr.: 2245230-79-7
4
4 Cited Publications
Target:
Forschungsgebiete:
MitoTEMPOL is a a mitochondria-targeted nitroxide that reduces mitochondrial O2 -to H2O2 .
4
4 Cited Publications
Art. -Nr.: HY-N0615
CAS. Nr.: 80418-24-2
Synonyms: Sanchinoside R1; Sanqi glucoside R1
3
Forschungsgebiete:
Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
3
2
2 Cited Publications
Art. -Nr.: HY-D1156A
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
