CORM-401
Based on 12 publication(s) in Google Scholar
CORM-401 is an oxidant-sensitive CO-releasing molecule. CORM-401 induces NO increase in the regulation of endothelial calcium signalling. CORM-401 reduces TNF-α/CHX and H2O2-induced ROS production. CORM-401 uncouples mitochondrial respiration and inhibits glycolysis.
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- Reinheit: 98.60%
- CAS. Nr.: 1001015-18-4
- Formel: C8H6MnNO6S2
- Molecular Weight:331.20
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) CORM-401
More- Adv Sci (Weinh). 2025 Jan 9:e2413833. [Abstract]
- Chem Eng J. 2025 Jul 15.
- Kidney Int. 2024 May 22:S0085-2538(24)00337-5. [Abstract]
- Mater Today Bio. 2025 Jan 11:31:101473. [Abstract]
- Biomater Res. 2024 Oct 29:28:0100. [Abstract]
- Int J Biol Macromol. 2024 Nov;279(Pt 1):135166. [Abstract]
- Int J Biol Macromol. 2024 May 18:132487. [Abstract]
- Surf Interfaces. 2025 Nov 8;77:108039.
- Biomater Adv. 2023 Jun:149:213393. [Abstract]
- Colloid Interface Sci Commun. 2025 Mar.
- Coatings. 2024 Nov 8.
- SSRN. 2024 Oct 25.
Biologische Aktivität
CORM-401 (100 μM; 1h) induces the NO production in endothelial EA.hy926 cells[1].
CORM-401 (30 μM) induces peak-like calcium signal and augmentes coupling of endoplasmic reticulum and plasmalemmal store-operated calcium channels[1].
CORM-401 (50 μM; 1h) significantly reduces TNF-α/CHX and H2O2-induced ROS production and cell death[2].
CORM-401 (0.5, 1 mM) induces a persistent increase in the oxygen consumption rate in endothelial EA.hy926 cells[3].
CORM-401 (10, 30, 100 μM) induces a concentration-dependent increase in OCR and a simultaneous decrease in ECAR[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1001015-18-4
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Appearance Solid
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Molecular Weight 331.20
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Formel C8H6MnNO6S2
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Color Light yellow to yellow
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SMILES
CN(C1=[S][Mn+](C#O)(C#O)(C#O)(C#O)[S-]1)CC([O-])=O.[H+]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (12)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
A Dual-Targeting Biomimetic Nanoplatform Integrates SDT/CDT/Gas Therapy to Boost Synergistic Ferroptosis for Orthotopic Hepatocellular Carcinoma Therapy. [Abstract]2025 Jan 9:e2413833. PMID: 39783849 -
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Kidney Int
Salvaging donated kidneys from prolonged warm ischemia during ex vivo hypothermic oxygenated perfusion. [Abstract]2024 May 22:S0085-2538(24)00337-5. PMID: 38789038 -
Mater Today Bio
Bivalirudin functionalized hydrogel coating capable of catalytical NO-generation for enhanced anticorrosion and biocompatibility of magnesium alloy. [Abstract]2025 Jan 11:31:101473. PMID: 39896280 -
Biomater Res
Two-Dimensional "Nanotanks" Release "Gas Bombs" through Photodynamic Cascades to Promote Diabetic Wound Healing. [Abstract]2024 Oct 29:28:0100. PMID: 39474320 -
Int J Biol Macromol
Constructing sodium alginate/carboxymethyl chitosan coating capable of catalytically releasing NO or CO for improving the hemocompatibility and endothelialization of magnesium alloys. [Abstract]2024 Nov;279(Pt 1):135166. PMID: 39214216 -
Int J Biol Macromol
A CO-releasing coating based on carboxymethyl chitosan-functionalized graphene oxide for improving the anticorrosion and biocompatibility of magnesium alloy stent materials. [Abstract]2024 May 18:132487. PMID: 38768910 -
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Biomater Adv
Fabrication of CO-releasing surface to enhance the blood compatibility and endothelialization of TiO2 nanotubes on titanium surface. [Abstract]2023 Jun:149:213393. PMID: 36966654 -
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Lösungsmittel & Löslichkeit
DMSO : 25 mg/mL (75.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (7.55 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (7.55 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Kaczara P, et al. CORM-401 induces calcium signalling, NO increase and activation of pentose phosphate pathway in endothelial cells. FEBS J. 2018 Apr;285(7):1346-1358. [Content Brief]
[2]. Babu D, et al. Differential Effects of CORM-2 and CORM-401 in Murine Intestinal Epithelial MODE-K Cells under Oxidative Stress. Front Pharmacol. 2017 Feb 8;8:31. [Content Brief]
[3]. Kaczara P, et al. Carbon monoxide released by CORM-401 uncouples mitochondrial respiration and inhibits glycolysis in endothelial cells: A role for mitoBKCa channels. Biochim Biophys Acta. 2015 Oct;1847(10):1297-309. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0193 mL | 15.0966 mL | 30.1932 mL | 75.4831 mL |
| 5 mM | 0.6039 mL | 3.0193 mL | 6.0386 mL | 15.0966 mL | |
| 10 mM | 0.3019 mL | 1.5097 mL | 3.0193 mL | 7.5483 mL | |
| 15 mM | 0.2013 mL | 1.0064 mL | 2.0129 mL | 5.0322 mL | |
| 20 mM | 0.1510 mL | 0.7548 mL | 1.5097 mL | 3.7742 mL | |
| 25 mM | 0.1208 mL | 0.6039 mL | 1.2077 mL | 3.0193 mL | |
| 30 mM | 0.1006 mL | 0.5032 mL | 1.0064 mL | 2.5161 mL | |
| 40 mM | 0.0755 mL | 0.3774 mL | 0.7548 mL | 1.8871 mL | |
| 50 mM | 0.0604 mL | 0.3019 mL | 0.6039 mL | 1.5097 mL | |
| 60 mM | 0.0503 mL | 0.2516 mL | 0.5032 mL | 1.2581 mL |
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