SIB-1757 (Standard)
SIB-1757 (Standard) is the analytical standard of SIB-1757 (HY-102095). This product is intended for research and analytical applications. SIB-1757 is a highly selective and noncompetitive antagonist of mGlu5 receptor with an IC50 of 0.4 μM.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 31993-01-8
- Formel: C12H11N3O
- Molecular Weight:213.24
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
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HY-102095
SIB-1757mGluR5 antagonist -
HY-14609A
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NPS 2390CaSR/mGluR1/5 Allosteric Antagonist -
HY-100804R
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HY-100403
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HY-101356
CPCCOEtmGluR1b Antagonist -
HY-103558
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HY-103568
YM-298198 hydrochloridemGluR1 Antagonist
Product Information
Information
Anwendung
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS. Nr. 31993-01-8
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Molecular Weight 213.24
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Formel C12H11N3O
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SMILES
OC1=CC=C(C)N=C1/N=N/C2=CC=CC=C2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Varney MA, et al. SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5. J Pharmacol Exp Ther. 1999 Jul;290(1):170-81. [Content Brief]
[2]. Storto M, et al. Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. J Hepatol. 2003 Feb;38(2):179-87. [Content Brief]
[3]. Dogrul A, et al. Peripheral and spinal antihyperalgesic activity of SIB-1757, a metabotropic glutamate receptor (mGLUR(5)) antagonist, in experimental neuropathic pain in rats. Neurosci Lett. 2000 Oct 6;292(2):115-8. [Content Brief]
[4]. Bonsi P, et al. Modulatory action of metabotropic glutamate receptor (mGluR) 5 on mGluR1 function in striatal cholinergic interneurons. Neuropharmacology. 2005;49 Suppl 1:104-13. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
SIB-1757 (Standard) Related Classifications
HY-102095R Related Classifications
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