T808
Based on 1 Customer Validation
T808 is a selective tau protein-targeting ligand. T808 can be used to synthesize [18F]-T808, a highly selective tau protein positron emission tomography (PET) tracer. T808 can also be used to synthesize [3H]-T808, a marker for in vitro experiments. T808 can be used for the research of alzheimer’s disease.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 98.20%
- CAS. Nr.: 1320211-61-7
- Formel: C17H19FN4
- Molecular Weight:298.36
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
T808 (10 μM; 120 min; mouse liver microsomes assay) is rapidly metabolized in the presence of NADPH, while 85% remains intact after 2 h incubation without NADPH[2].
T808 (10 μM; 120 min; human liver microsomes assay) is more metabolically stable, with 30% remaining intact after 2 h incubation with NADPH and over 93% intact without NADPH[2].
T808 (1 μM, 3 μM) shows no significant inhibition against 72 common CNS targets, with only weak inhibition on norepinephrine transporter 1 (IC50 = 0.82 μM) and monoamine transporter (IC50 = 2.7 μM)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 1320211-61-7
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Appearance Solid
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Molecular Weight 298.36
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Formel C17H19FN4
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Color White to off-white
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SMILES
FCCC1CCN(C2=NC3=NC4=CC=CC=C4N3C=C2)CC1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 50 mg/mL (167.58 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.38 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (271 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.3517 mL | 16.7583 mL | 33.5166 mL | 83.7914 mL |
| 5 mM | 0.6703 mL | 3.3517 mL | 6.7033 mL | 16.7583 mL | |
| 10 mM | 0.3352 mL | 1.6758 mL | 3.3517 mL | 8.3791 mL | |
| 15 mM | 0.2234 mL | 1.1172 mL | 2.2344 mL | 5.5861 mL | |
| 20 mM | 0.1676 mL | 0.8379 mL | 1.6758 mL | 4.1896 mL | |
| 25 mM | 0.1341 mL | 0.6703 mL | 1.3407 mL | 3.3517 mL | |
| 30 mM | 0.1117 mL | 0.5586 mL | 1.1172 mL | 2.7930 mL | |
| 40 mM | 0.0838 mL | 0.4190 mL | 0.8379 mL | 2.0948 mL | |
| 50 mM | 0.0670 mL | 0.3352 mL | 0.6703 mL | 1.6758 mL | |
| 60 mM | 0.0559 mL | 0.2793 mL | 0.5586 mL | 1.3965 mL | |
| 80 mM | 0.0419 mL | 0.2095 mL | 0.4190 mL | 1.0474 mL | |
| 100 mM | 0.0335 mL | 0.1676 mL | 0.3352 mL | 0.8379 mL |
T808 Related Classifications
HY-101185 Related Classifications
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